alexa A New Era in Functional Genomics Using CRISPR/Cas9 Knockout Screening | OMICS International| Abstract

ISSN: 1747-0862

Journal of Molecular and Genetic Medicine

  • Commentary   
  • J Mol Genet Med 2018, Vol 12(2): 345
  • DOI: 10.4172/1747-0862.1000345

A New Era in Functional Genomics Using CRISPR/Cas9 Knockout Screening

Wenzhi Cai1,5#, Weijing Li2,5#, Dan Yang3, Huafeng Xie4 and Jian Huang5*
1Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, , Suzhou, PR China
2Hematology and Oncology Laboratory, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, PR China
3Wuhan Institute of Design and Sciences, , Wuhan, PR China
4Institute for Life Sciences, South China University of Technology, Guangzhou, PR China
5Department of Pathology and Laboratory Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA
#Contributed equally to this work
*Corresponding Author : Dr. Jian Huang, Department of Pathology and Laboratory Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia Pennsylvania, 19140, USA, Tel: 215-707-2647, Email: [email protected]

Received Date: Mar 23, 2018 / Accepted Date: Apr 05, 2018 / Published Date: Apr 09, 2018

Abstract

In this commentary, we discussed the new exciting progress in CRISPR based screening technology field and highlight recent developments in the area of CRISPR-based functional genomics. High-throughput functional genomics using CRISPR-Cas9 revolutionized our ability to decipher cellular function in health and disease. Despite its limitations, the simplicity and effectiveness of CRISPR/Cas9 based screening, makes an enormous impact on genomic screening and thus scientific discovery.

Keywords: Genome-editing; CRISPR based screening; Genetic screening

Citation: Cai W, Li W, Yang D, Xie H, Huang J (2018) A New Era in Functional Genomics Using CRISPR/Cas9 Knockout Screening. J Mol Genet Med 12: 345 Doi: 10.4172/1747-0862.1000345

Copyright: © 2018 Cai W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

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