A New HPLC Method for Analysis of Natural Monacolin K in Red YeastRice Pharmaceutical PreparationsSabry OMM*
Pharmacognosy Department-Faculty of Pharmacy, Cairo University, Cairo-11562, Egypt
- *Corresponding Author:
- Omar MM Sabry
Pharmacognosy Department-Faculty of Pharmacy, Cairo University
E-mail: [email protected]
Received date: September 07, 2015; Accepted date: October 06, 2015; Published date: October 10, 2015
Citation: Sabry OMM (2015) A New HPLC Method for Analysis of Natural Monacolin K in Red Yeast Rice Pharmaceutical Preparations. J Pharmacogn Nat Prod 1:106. doi: 10.4172/2472-0992.1000106
Copyright: © 2015 Sabry OMM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Monacolin K (lovastatin or mevinolin) is a naturally occurring hypocholesterolemic statin used to prevent cardiovascular diseases for those persons suffering from hypercholesterolemia, a condition characterized by very high levels of cholesterol in the blood. It is originally derived from the fungus Monascus ruber and Monascus purpureus family Monascaceae. Monacolin K is a lactone polyketide derived compound converted in the body to the active form, B-hydroxy acid of monacolin K. It acts by inhibiting the hepatic HMG-CoA Reductase enzyme. In this paper, we report a selective precise and accurate new HPLC method for analysis of both lactone form and acid form of monacolin k in red rice pharmaceutical preparations.