A New Protocol to Discover Novel Anti-Aging CompoundsFumiaki Uchiumi1,2*, Takahiro Oyama1, Kensuku Ozaki1, Megumi Fukui1, Hisui Ogawa1, Yuki Sasaki1, Haruki Tachibana3, Chisato Fukushima3, Makoto Fujikawa3, Hideaki Abe4, Steven Larsen2 and Sei-ichi Tanuma2,3
- *Corresponding Author:
- Fumiaki Uchiumi, Ph.D
Department of Gene Regulation
Faculty of Pharmaceutical Sciences, Tokyo University of Science
2641 Yamazaki, Noda-shi, Chiba-ken 278-8510, Japan
E-mail: [email protected]
Received date: September 28, 2012; Accepted date: October 08, 2012; Published date: October 12, 2012
Citation: Uchiumi F, Oyama T, Ozaki K, Fukui M, Ogawa H, et al. (2012) A New Protocol to Discover Novel Anti-Aging Compounds. Pharmaceut Anal Acta 3:166. doi:10.4172/2153-2435.1000166
Copyright: © 2012 Uchiumi F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Several natural and chemical compounds have been suggested to have effects as anti-aging drugs. For example, caloric restriction (CR) mimetics trans-resveratrol (Rsv) and 2-deoxy-D-glucose (2DG) are candidate compounds that can elongate life span of organisms, and they might also have roles in the regulation of telomere maintenance and mitochondrial functions. Recently, pharmaceutical medicaments rapamycin, an immunosuppressant and metformin, a medicine for diabetes, have been shown to act on the insulin/IGF1 signaling pathway. Therefore, they are also expected to have anti-aging effects. Here we propose a new protocol to discover novel compounds that can be used as a remedy to slow senescence and control aging in the aspect of promoter activities of telomere and energy metabolism-regulating factor encoding genes.