A New Synthetic Diet Increased Bone Mineral Density and Strength of Ovariectomized Rat
- Corresponding Author:
- Hiroshi Nakada
Department of Removable Prosthodontics
Nihon University School of Dentistry at Matsudo
Chiba 271-8587, Japan
E-mail: [email protected]
Received date: June 08, 2013; Accepted date: July 22, 2013; Published date: August 22, 2013
Citation: Nakada H, Watanabe T, Takahashi T, Fujita K, Tanimoto Y, et al. (2013) A New Synthetic Diet Increased Bone Mineral Density and Strength of Ovariectomized Rat. Bioceram Dev Appl S1:003. doi:10.4172/22090-5025.S1-003
Copyright: © 2013 LNakada H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
This study aimed to determine changes in Bone Mineral Density (BMD) and bone strength of ovariectomized rats fed a synthetic diet of Mg, Zn, and F incorporated with carbonate apatite. Group 1 (n=4) was fed a Normal Mineral Diet (NMD) and Group 2 (n=4) was fed the Synthetic Diet (SD: 0.74% Ca, 0.48% P, 0.10% Mg, 365.4 ppm Zn, 51.01 ppm F and 0.27% CO3). Rats were sacrificed after eight weeks and the femur was isolated. The micro-CT results showed that values of BMD for Group 2 were higher than those of Group 1. Bone strength values of Group 2 measured by a 3-point bending test were significantly higher than those of Group 1. These results indicated that Group 2 stimulated bone quality, increased BMD and bone strength. The SD has the potential to prevent bone loss and as an osteoporosis therapy.