alexa A New Synthetic Diet Increased Bone Mineral Density and
ISSN:2090-5025

Bioceramics Development and Applications
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Research Article

A New Synthetic Diet Increased Bone Mineral Density and Strength of Ovariectomized Rat

Hiroshi Nakada1 , Takehiro Watanabe1, Takahiro Takahashi1, Kanami Fujita1, Yasuhiro Tanimoto2, Mari Teranishi3, Takao Kato3, Yasuhiko Kawai1, Toshiro Sakae4 and Racquel Z LeGeros5

1Department of Removable Prosthodontics, Nihon University School of Dentistry at Matsudo, Chiba 271-8587, Japan

2Department of Dental Biomaterials, Nihon University School of Dentistry at Matsudo, Chiba 271-8587, Japan

3Department of Oral Implantology, Nihon University School of Dentistry at Matsudo, Chiba 271-8587, Japan

4Department of Histology, Nihon University School of Dentistry at Matsudo, Chiba 271-8587, Japan

5Department of Biomaterials and Biomimetics, New York University College of Dentistry, New York 10010, USA

Corresponding Author:
Hiroshi Nakada
Department of Removable Prosthodontics
Nihon University School of Dentistry at Matsudo
Chiba 271-8587, Japan
E-mail: [email protected]

Received date: June 08, 2013; Accepted date: July 22, 2013; Published date: August 22, 2013

Citation: Nakada H, Watanabe T, Takahashi T, Fujita K, Tanimoto Y, et al. (2013) A New Synthetic Diet Increased Bone Mineral Density and Strength of Ovariectomized Rat. Bioceram Dev Appl S1:003. doi:10.4172/22090-5025.S1-003

Copyright: © 2013 LNakada H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

This study aimed to determine changes in Bone Mineral Density (BMD) and bone strength of ovariectomized rats fed a synthetic diet of Mg, Zn, and F incorporated with carbonate apatite. Group 1 (n=4) was fed a Normal Mineral Diet (NMD) and Group 2 (n=4) was fed the Synthetic Diet (SD: 0.74% Ca, 0.48% P, 0.10% Mg, 365.4 ppm Zn, 51.01 ppm F and 0.27% CO3). Rats were sacrificed after eight weeks and the femur was isolated. The micro-CT results showed that values of BMD for Group 2 were higher than those of Group 1. Bone strength values of Group 2 measured by a 3-point bending test were significantly higher than those of Group 1. These results indicated that Group 2 stimulated bone quality, increased BMD and bone strength. The SD has the potential to prevent bone loss and as an osteoporosis therapy.

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