alexa A New Β-Triketone and Antinociceptive Effect fro
ISSN: 2167-0412

Medicinal & Aromatic Plants
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Research Article

A New Β-Triketone and Antinociceptive Effect from the Essential Oil of the Leaves of Calyptranthes restingae Sobral (Myrtaceae) LO1, Pina LTS2, de Jesus AM1, de Melo MS1, Bispo RM1, Alves PB1, de Lima PCN1, de Souza VRM1, Silva GH1, Júnior LJQ2, Thomazzi SM2, Martins LRR3, Ferreira AG4, de Souza AR5, Machado SMF1 and Guimarães AG6*

1Department of Chemistry, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil

2Department of Physiology, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil

3Department of Chemistry and Biology, Federal University Technology of State Paraná, Curitiba, Paraná, Brazil

4Department of Chemistry, Federal University of São Carlos, São Carlos, São Paulo, Brazil

5Department of Biology, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil

6Department of Health Education, Federal University of Sergipe, Lagarto, Sergipe, Brazil

Corresponding Author:
Guimarães AG
Department of Health Education
Federal University of Sergipe, Padre Álvares Pitangueira
Street No 248, Center, Lagarto/SE, Brazil
Tel: +557921056645
Fax: +557932126640
E-mail: [email protected]/[email protected]

Received March 09, 2016; Accepted April 25, 2016; Published April 28, 2016

Citation: Passos LO, Pina LTS, de Jesus AM, de Melo MS, Bispo RM, et al. (2016) A New Β-Triketone and Antinociceptive Effect from the Essential Oil of the Leaves of Calyptranthes restingae Sobral (Myrtaceae). Med Aromat Plants 5:249. doi:10.4172/2167-0412.1000249

Copyright: © 2016 Passos LO, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Calyptranthes restingae Sobral, known as “murta”, is a species of the northeastern Brazilian used to treat fever, pain and inflammatory disorders. The essential oil from Calyptranthes restingae Sobral (Myrtaceae) collected in Sergipe, northeastern Brazil, was obtained through the hydrodistillation and its antinociceptive properties were evaluated. Chromatographic analysis revealed 14 components, but only five were identified, accounting for 98.50% of the oil: (E)-caryophyllene (2.40%), calyptrantone (81.03%), α-humulene (1.52%), β-selinene (8.54%), α-selinene (5.01%). The structure of the major compound, calyptrantone, was elucidated by 1H and 13C-NMR. This is the first time that a β-triketone has been identified in the essential oil of Calyptranthes genus and that calyptrantone has been reported as a natural product. This essential oil showed an antinociceptive effect in mice, reducing acetic-acidinduced abdominal writhing significantly in comparison with the control group (p<0.001), with the possible participation of opioids. In the formalin test, the oil also caused significant inhibition of licking time in both phases without loss of motor coordination. Besides, all doses of the oil decreased the leukocyte migration in peritoneal cavity induced by carrageenan (p<0.01). Together, these results indicate that the essential oil of C. restingae represents an important potential tool for management of neurogenic and inflammatory pain.


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