A Novel Approach to Combat Acquired Multiple Resistance in Escherichia coli by using EDTA as Efflux Pump Inhibitor
Manu Chaudhary, Shailesh Kumar and Anurag Payasi*
Department of Cell Culture and Molecular Biology, Venus Medicine Research Centre, Baddi, H.P. India
- *Corresponding Author:
- Anurag Payasi
Venus Medicine Research Centre
Hill Top Industrial Estate
Bhatoli Kalan, Baddis
Tel: 91-1795- 302005
E-mail: [email protected]
Received Date: September 26, 2012; Accepted Date: October 25, 2012; Published Date: October 29, 2012
Citation: Chaudhary M, Kumar S, Payasi A (2012) A Novel Approach to Combat Acquired Multiple Resistance in Escherichia coli by using EDTA as Efflux Pump Inhibitor. J Microb Biochem Technol 4:126-130. doi: 10.4172/1948-5948.1000082
Copyright: © 2012 Chaudhary M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Escherichia coli is one of the leading pathogen responsible for severe ICU infections and have evolved a variety of strategies to resist antibiotics. A single resistance mechanism may diminish susceptibility to several therapeutic drugs allowing the survival of bacteria in their niches. Among the various resistance mechanisms, antibiotic removal from the bacterial cells by efflux pumps are most common. There are a number of reports indicating antibiotic resistance because of efflux pump in bacteria is increasing significantly. Therefore, antibiotic efflux pumps are thought of as attractive therapeutic targets, where their inhibition can restore antibiotic activity.