A Novel Approach to Formulate and Optimize Orally Disintegrating Tablets of Bambuterol HydrochlorideLiandong Hu*, Deliang Gu, Qiaofeng Hu, Hailei Zhang and Xun Yang
College of Pharmacy, Hebei University and Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, 071002, China
- *Corresponding Author:
- Liandong Hu
College of Pharmacy
Hebei University and Key Laboratory of Pharmaceutical
Quality Control of Hebei Province, Hebei University
Baoding, 071002, China
E-mail: [email protected]
Received date: January 14, 2013; Accepted date: March 14, 2013; Published date: March 24, 2013
Citation:Hu L, Gu D, Hu Q, Zhang H, Yang X (2013) A Novel Approach to Formulate and Optimize Orally Disintegrating Tablets of Bambuterol Hydrochloride. Pharmaceut Anal Acta 4:216. doi: 10.4172/2153-2435.1000216
Copyright: © 2013 Hu L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The aim of this article was to choose the optimal ingredients for oral disintegrating tablets of bambuterol hydrochloride (BBH) and use a novel approach to measure disintegration time. The disintegration time measured by a new approach was compared with disintegration time measured in oral cavity and conventional disintegration test. The result shows that the new apparatus is suitable for measuring the disintegration time. The effect of ingredients (diluents, disintegrants and adhesives) on the characteristics of the tablets was investigated. The orally disintegrating tablets of BBH were prepared by wet granulation. The results showed that the optimum proportion was 10 mg BBH, 100 mg lactose, 80 mg MCC, 10 mg crospovidone (PVPP), 2 mg aspartame, 2 mg DL-malic acid. The orally disintegrating tablet disintegrated rapidly, tasted good and could be taken convenient.