alexa A Novel Approach to Inactivate the Clinical Isolates of
ISSN: 1948-5948

Journal of Microbial & Biochemical Technology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

A Novel Approach to Inactivate the Clinical Isolates of Trichophyton mentagrophytes and Trichophyton rubrum by Using Non-Thermal Plasma

Anser Ali1,2, Young June Hong2,3, Jihoon Park2,3, SeungHyun Lee1,2, Eun Ha Choi1,2,3, Gi Chung Kwon2,3* and Bong Joo Park2,3*

1Department of Plasma Bioscience and Display, Kwangwoon University, Republic of Korea

2Plasma Bioscience Research Center, Kwangwoon University, Republic of Korea

3Department of Electrical and Biological Physics, Kwangwoon University, Republic of Korea

These authors contributed equally to this work

*Corresponding Author:
Gi Chung Kwon
Department of Electrical and Biological Physics and Plasma Bioscience Research Center
Kwangwoon University
20 Kwangwoon-gil, Nowon-gu
Seoul 139-701, Republic of Korea
Tel: +82-2-940- 5479
Fax: +82-2-940-5664
E-mail: [email protected]

Bong Joo Park
Department of Electrical and Biological Physics and Plasma Bioscience Research Center
Kwangwoon University, 20 Kwangwoon-gil
Nowongu, Seoul 139-701, Republic of Korea
Tel: +82-2-940-8629
Fax: +82-2-940-5664;
E-mail: [email protected]

Received date: June 17, 2014; Accepted date: July 05, 2014; Published date: July 11, 2014

Citation: Ali A, Hong YJ, Park J, Lee SH, Choi EH, et al. (2014) A Novel Approach to Inactivate the Clinical Isolates of Trichophyton mentagrophytes and Trichophyton rubrum by Using Non-Thermal Plasma. J Microb Biochem Technol 6:314-319. doi: 10.4172/1948-5948.1000161

Copyright: © 2014 Ali A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

 

Abstract

In this study, we propose a novel approach that uses non-thermal plasma to inactivate dermatophytes, and we evaluate the antifungal activity of the proposed method using an In vitro infected skin model with clinical isolates of dermatophytes. For this study, a floating electrode-dielectric barrier discharge (FE-DBD) plasma jet was the source for non-thermal plasma, and we investigated its antifungal activity on Trichophyton mentagrophytes (T. mentagrophytes) and Trichophyton rubrum (T. rubrum), two clinical isolates of dermatophytes. These two strains are the most frequently isolated from skin, hair, and nail infections for use in an infected skin model. The results of this study confirm that the FE-DBD plasma jet has statistically significant antifungal activity in saline and in an infected skin model, and after plasma treatment; we also observed a significant inhibition of the growth of the conidia and hypha for both strains in the infected skin mimicking model. In addition, we found a time-dependent correlation between the intracellular reactive species and the fungal cell viabilities after exposure to plasma. These results indicate FE-DBD plasma can inactivate clinically isolated dermatophyte species and suggest that non-thermal plasma may be an effective tool for use in supportive and/or alternative treatments for dermatophytosis.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords