A Novel Chemical Solution to Demineralize Vascular Calcification in Ex-Vivo Amputated Limbs
- *Corresponding Author:
- Yamani MH
Departments of Vascular Surgery, Cardiology
Mayo Clinic Florida, Davis 7E, 4500 San Pablo Rd
Jacksonville, FL 32224, USA
E-mail: [email protected]
Received Date: March 30, 2016; Accepted Date: April 18, 2016; Published Date: April 25, 2016
Citation: Farres H, Yamani MH, Moualla S, Pharm PF, Hakaim A (2016) A Novel Chemical Solution to Demineralize Vascular Calcification in Ex-Vivo Amputated Limbs. J Vasc Med Surg 4:262. doi:10.4172/2329-6925.1000262
Copyright: © 2016 Farres H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The study was performed to evaluate the ex-vivo demineralizing efficacy of a novel chemical solution, combined L(+) lactic acid and D-gluconic acid (LAGA), in calcified peripheral arteries of 2 patients who underwent limb amputation. Angiography was obtained at baseline and after local installation of the 20 ml of LAGA solution in the occluded arteries. A significant dissolution of the calcification with restoration of patency of the occluded arteries was noted. LAGA solution is efficacious in demineralizing calcific peripheral arteries. Our study may pave the way for potential novel therapeutic strategies to treat patients with calcified peripheral arterial disease.