alexa A Novel Chemical Solution to Demineralize Vascular Calc
ISSN: 2329-6925

Journal of Vascular Medicine & Surgery
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Research Article

A Novel Chemical Solution to Demineralize Vascular Calcification in Ex-Vivo Amputated Limbs

Farres H1, Yamani MH2*, Moualla S2, Fuqua P3 and Hakaim A1

1Departments of Vascular Surgery, Mayo Clinic Florida, Jacksonville, USA

2Cardiovascular Medicine, Mayo Clinic Florida, Jacksonville, USA

3Pharmacy, Mayo Clinic Florida, Jacksonville, USA

*Corresponding Author:
Yamani MH
Departments of Vascular Surgery, Cardiology
Mayo Clinic Florida, Davis 7E, 4500 San Pablo Rd
Jacksonville, FL 32224, USA
Tel: (904)953-7279
Fax: (904)953-2911
E-mail: [email protected]

Received Date: March 30, 2016; Accepted Date: April 18, 2016; Published Date: April 25, 2016

Citation: Farres H, Yamani MH, Moualla S, Pharm PF, Hakaim A (2016) A Novel Chemical Solution to Demineralize Vascular Calcification in Ex-Vivo Amputated Limbs. J Vasc Med Surg 4:262. doi:10.4172/2329-6925.1000262

Copyright: © 2016 Farres H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The study was performed to evaluate the ex-vivo demineralizing efficacy of a novel chemical solution, combined L(+) lactic acid and D-gluconic acid (LAGA), in calcified peripheral arteries of 2 patients who underwent limb amputation. Angiography was obtained at baseline and after local installation of the 20 ml of LAGA solution in the occluded arteries. A significant dissolution of the calcification with restoration of patency of the occluded arteries was noted. LAGA solution is efficacious in demineralizing calcific peripheral arteries. Our study may pave the way for potential novel therapeutic strategies to treat patients with calcified peripheral arterial disease.


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