A Novel Potentiometric Titration Method for Quantitative Determination of Bromide Content in Doxorubicin Hydrochloride
A simple precise, rapid accurate and sensitive Potentiometric titration method was developed for quantitative determination of Bromide content in Doxorubicin Hydrochloride. The titration was carried out by using standardized 0.1 N Silver Nitrate solutions (AgNO3). To confirm the presence of bromide content spiking study was carried out by spiking 0.1% NaBr into the test preparations which shows the 0.1 % increase in the % Cl of the actual % Cl. The end point was determined by using Mettler T 50 Auto titrator with DM 141 SC electrode. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r2 > 0.999) between 0.5% to 4.0%. The percentage recovery of Bromide in the optimized method was between 96.3 % to 96.7 %.