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Journal of Multiple Sclerosis
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  • Research Article   
  • J Mult Scler,
  • DOI: 10.4172/2376-0389.1000218

A Pilot Investigation of Natural Killer Cell Function and Phenotypes in Stable and Active Multiple Sclerosis Patients

Helene Cabanas1,2#, Natalie Eaton1,2*#, Ellie Khalilidehkordi2#, Simon Broadly2, Cassandra Balinas1,2, Stanley Du Preez1,2, Rebekah Maksoud1,2, Donald Staines1,2 and Sonya Marshall-Gradisnik1,2
1School of Medical Science, Griffith University, Gold Coast, QLD, Australia
2The National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia
#Contributed equally to this work
*Corresponding Author : Natalie Eaton, Menzies Health Institute Queensland, National Centre for Neuroimmunology and Emerging Diseases, Southport, QLD 4222, Australia, Tel: +61756789283, Email: [email protected]

Received Date: Jan 20, 2018 / Accepted Date: Feb 19, 2018 / Published Date: Feb 26, 2018

Abstract

Background: Previous studies have reported impaired cytotoxic activity in Natural Killer (NK) CD56Dim and CD56Bright cell phenotypes in peripheral blood associated with Multiple Sclerosis (MS). Recently it has been suggested that NK cell phenotype could be associated with new lesions on Magnetic resonance imaging (MRI) and may be used as an immunological indicator of disease activity. This project, for the first time, investigates NK cell cytotoxicity in MS patients with active and stable lesions.
Methods: NK cell cytotoxic activity and NK CD56Dim and CD56Bright cell phenotypes were examined in MS patients using flow cytometry. Isolated NK cells were labelled with antibodies to determine CD56Dim and CD56Bright NK cells and cytotoxic function using target cells (K562). Seven patients (aged 38.0 ± 3.21) with stable Relapsing Remitting MS (RRMS) who had previously received alemtuzumab (Lemtrada®), five patients with active MS (aged 32.66 ± 5.17) on nil medication and five healthy controls (aged 34.4 ± 6.12) participated.
Results: There were no significant differences for NK cell cytotoxic activity and NK CD56Dim and CD56Bright phenotypes between stable RRMS, active RRMS and healthy controls.
Conclusion: Clear associations between NK cell cytotoxicity and clinical MS subtypes in this study were not identified.

Keywords: Natural killer cell function; Natural killer phenotypes; Multiple sclerosis

Citation: Cabanas H, Eaton N, Khalilidehkordi E, Broadly S, Balinas C, et al. (2018) A Pilot Investigation of Natural Killer Cell Function and Phenotypes in Stable and Active Multiple Sclerosis Patients. J Mult Scler (Foster City) 5: 218. Doi: 10.4172/2376-0389.1000218

Copyright: © 2018 Cabanas H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

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