alexa A Possible Interconnection of Cholesterol Overloading and Phagocytic Activity of the Monocytes in the Prone to Rheumatoid Arthritis Individuals

Lupus: Open Access
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

A Possible Interconnection of Cholesterol Overloading and Phagocytic Activity of the Monocytes in the Prone to Rheumatoid Arthritis Individuals

Marina I. Arleevskaya1*, Aleksey Zabotin2, Aida Gabdoulkhakova1, Julia Filina1 and Anatoly Tsibulkin2

1Central Research Laboratory, Kazan State Medical Academy, Kazan, Russia

2Institute of Biochemistry and Biophysics, Russian Academy of Science, Kazan, Russia

*Corresponding Author:
Marina I. Arleevskaya
Central Research Laboratory
Kazan State Medical Academy, Russia
Tel: +7 843 2365053
E-mail: [email protected]

Received date: January 04, 2016; Accepted date: February 24, 2016; Published date: March 17, 2016

Citation:Arleevskaya MI, Zabotin A, Gabdoulkhakova A, Filina J, Tsibulkin A (2016) A Possible Interconnection of Cholesterol Overloading and Phagocytic Activity of the Monocytes in the Prone to Rheumatoid Arthritis Individuals . Lupus Open Access 1:112.

Copyright: © 2016 Arleevskaya MI, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: The abnormalities of lipid metabolism were demonstrated in the individuals, who later develop rheumatoid arthritis (RA). Trivial infections are known to contribute to atherosclerosis. We showed that first degree relatives of RA patients suffer from frequent and lingering trivial infections. The interconnection between the disturbance of lipid metabolism and the increased trivial infection burden is hypothesized in this group. Mononuclear phagocytes (MP) are the important players in RA pathogenesis, antiinfectious defense and atherosclerosis. The aim was to investigate the interconnection between the involvement of MPs in cholesterol metabolism, their phagocytic activity and the burden of trivial infections in the RA patients, their relatives and healthy individuals without autoimmune diseases in family history. Methods: The following parameters were studied: intracellular cholesterol content (colorimetric), membrane cholesterol content and microviscosity (fluorescent), engulfment and digestion (radioisotope); reactive oxygen species generation (chemiluminescence). Results: In relatives MPs and their cell membranes were overloaded with cholesterol; microviscosity of cell membranes and membrane annular lipid regions was increased, cholesterol accumulation in the cells being in strong correlation with the incidence and duration of the trivial infections. In RA group only increased microviscosity of annular lipid regions was revealed. In the patient and relative groups the delayed engulfment and the slowed down time to reach the peak of reactive oxygen species generation after MP stimulation were revealed. Conclusion: We speculate that the abnormalities in monocyte – cholesterol interaction can exacerbate the insufficiency of antiinfectious defense and promote the aggravation of the infectious syndrome, which is known to be a risk factor of RA.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

socia[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version