A Preliminary Study to Predict the Ingested Dose of Doxylamine from its Plasma Concentration in the Korean Patients with Doxylamine Intoxication
2Department of Pharmacology and Clinical Pharmacology Lab, College of Medicine, Division of Molecular Therapeutics Development, Hanyang Biomedical Research Institute, Hanyang University, Seoul 133-791, South Korea
- *Corresponding Author:
- Ju-Seop Kang
Department of Pharmacology and
Clinical Pharmacology Lab
College of Medicine, Hanyang University
Seoul 133-791, South Korea
E-mail: [email protected]
Received Date: December 29, 2012; Accepted Date: January 31, 2013; Published Date: February 05, 2013
Citation: Kim SW, Kang JS, Park YS, Kim SH, Kim HJ, et al. (2013) A Preliminary Study to Predict the Ingested Dose of Doxylamine from its Plasma Concentration in the Korean Patients with Doxylamine Intoxication. Emergency Med 3:133. doi:10.4172/2165-7548.1000133
Copyright: © 2013 Kim SW, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Doxylamine succinate, over-the-counter antihistamine, is commonly used as a nighttime sleep-aid and is world-wide ingested in overdoses when one attempts a suicide because of its easy accessibility. The objective of this study was aimed to find out models to predict the ingested amount of doxylamine from its blood concentrations of thirty Korean patients with doxylamine intoxication.
Method: Thirty patients who were admitted to two emergency centers through Jul, 2006 to Jul, 2008 due to doxylamine overdose were recruited. In all patients, demographic information and clinical variables, arrival time to the hospital after doxylmamine overdose, amount of doxylamine ingested, and vomiting were evaluated.
Results: Of these thirty patients, average ingestion amount of doxylamine was 750 mg (range, 200~2500 mg). The mean arrival time to the hospital after the doxylamine ingestion was 4.5 h (range, <1.0~24 h) and its mean blood level at arrival time was 3.15 μg/mL (range, 0.64~11.31 μg/mL). Ingested doxylamine dose was predicted by determining the coefficient of plasma drug concentration using stepwise regression analysis. The linear regression formula calculated was: y=241.769(x)+217.117 (y=ingested doxylamine dose, x=its plasma concentration, p=0.001).
Conclusion: Close clinical observation, laboratory follow-up and analysis of blood doxylamine concentration were required for patients, who intoxicated doxylamine and admitted emergency department, to estimate ingested dose and time of doxylamine, and to prevent the clinical toxicity. We suggested that recommended sampling time for analysis of plasma doxylamine concentration was 1~3 h after the ingestion, and its plasma level at the arrival time was a statistically significant factor to predict the ingested dose of doxylamine in the 30 Korean patients with doxylamine intoxication.