alexa A Program for Optimizing the Use of Antibiotics in the
ISSN: 2472-1212

Journal of Antimicrobial Agents
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Short Communication

A Program for Optimizing the Use of Antibiotics in the Hospital Setting: Experience in a Spanish Regional Hospital

Jon Ugalde-Espiñeira1*, Jaione Bilbao-Aguirregomezcorta2 and Ainhoa Zuriñe Sanjuan-López1

1Service of Internal Medicine, Hospital San Eloy, Integrated Health Care Organization, Barakaldo-Sestao, Barakaldo, Spain

2Service of Hospital Pharmacy, Hospital San Eloy, Integrated Health Care Organization Barakaldo-Sestao, Barakaldo, Spain

*Corresponding Author:
Jon Ugalde Espiñeira, MD
Servicio de Medicina Interna
Hospital San Eloy
Organización Sanitaria Integrada Barakaldo-Sestao
Avda Antonio Miranda 5
E-48902, Barakaldo, Spain
Tel: +34 94 4006700
Fax: +34 94 4006727
E-mail: [email protected]

Received date: October 03, 2016; Accepted date: October 31, 2016; Published date: November 07, 2016

Citation: Ugalde-Espiñeira J, Bilbao-Aguirregomezcorta J, Sanjuan-López AZ (2016) A Program for Optimizing the Use of Antibiotics in the Hospital Setting: Experience in a Spanish Regional Hospital. J Antimicrob Agents 2:128. doi:10.4172/2472-1212.1000128

Copyright: © 2016 Ugalde-Espiñeira J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



We here describe the implementation of a program for optimizing the use of antibiotics (PROA) in a 128-bed regional hospital in Barakaldo, Spain, and the results obtained at 6 months. The study was a quasi-experimental prospective intervention study using a historical control group. A non-restrictive intervention model to help prescription, with a direct and bidirectional intervention was developed. The program consisted of an optimization audit of the use of antibiotics without pre-established personalized guidelines. Variables assessed included antibiotic consumption and costs, cost per process, mean hospital stay, and percentage of hospital readmissions. Data obtained during the 6-month study period (November 2013-April 2014) were compared with data collected between November 2012 and April 2013. A total of 307 audits were performed. In 65.8% of cases, treatment was discontinued between the 7th and the 10th day. The main reasons of treatment discontinuation were completeness of treatment (43.6%) and lack of indication (14.7%). The reduction of pharmaceutical expenditure was 8.59% (P=0.049) and 5.61% of the consumption in defined daily dose (DDD)/100 stays (P=0.180). The costs by processes in general surgery showed a 3.14% decrease (P=0.001). These results confirm the efficiency of implementing programs for optimizing the use of antibiotics in medium-sized hospitals with limited resources.


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