alexa A Proposal of The New Mechanism on Remnant Lipoprotein Formation and Clearance after Food Intake
ISSN: 2329-8847

Journal of Aging Science
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Review Article

A Proposal of The New Mechanism on Remnant Lipoprotein Formation and Clearance after Food Intake

Katsuyuki Nakajima* and Akira Tanaka

Laboratory of Clinical Nutrition and Medicine, Kagawa Nutrition University, Tokyo, Japan

*Corresponding Author:
Katsuyuki Nakajima
Laboratory of Clinical Nutrition and Medicine
Kagawa Nutrition University, Tokyo, Japan
Tel: 81-27-243-6390
Fax: + 81-27-243-6390
E-mail: [email protected]

Received date: February 03, 2017; Accepted date: March 06, 2017; Published date: March 08, 2017

Citation: Nakajima K, Tanaka A (2017) A Proposal of The New Mechanism on Remnant Lipoprotein Formation and Clearance after Food Intake. J Aging Sci 5:173. doi:10.4172/2329-8847.1000173

Copyright: © 2017 Nakajima K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



To understand the mechanism of plasma TG increase after food intake, the characteristics of remnant lipoproteins in postprandial plasma and the role of lipoprotein lipase (LPL) were investigated. The accumulation of TG in remnant lipoproteins (RLP-TG) is caused by the unchanged levels of LPL activity for hydrolysis of chylomicrons and VLDL when overloaded at endothelium after food intake. This review proposed a new hypothesis on the metabolism of plasma TG-rich lipoprotein based on the no-change of LPL activity at endothelium after food intake and the discovery of RLP-LPL complex in postprandial plasma.


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