alexa A Prospective Randomized Controlled Trial to Assess the Effect of Intravenous versus Oral Iron Therapy in the Treatment of Preoperative Anaemia | OMICS International | Abstract
ISSN: 2155-9864

Journal of Blood Disorders & Transfusion
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Research Article

A Prospective Randomized Controlled Trial to Assess the Effect of Intravenous versus Oral Iron Therapy in the Treatment of Preoperative Anaemia

Alhossain Khalafallah1,2,3*, Abdul Majeed Al-Barzan3, Johan Chan2, Mei Fen Sung2, Gerald Bates1,3, Kiran DK Ahuja3, John C Batten4 and Bernie Einoder4

1Launceston General Hospital, Launceston, Tasmania, Australia

2Clinical School of Medicine, Launceston, University of Tasmania, Australia

3School of Human Life Sciences, University of Tasmania, Australia

4Department of Orthopaedic Surgery, Launceston General Hospital, Launceston, Tasmania, Australia

*Corresponding Author:
Alhossain Khalafallah, M.D.
Associate Professor, Consultant Haematologist
The Launceston General Hospital
Launceston Tasmania, 7250, Australia
Tel: +61-3-63487111
Fax: +61-3-63353388
E-mail: [email protected]/[email protected]

Received date:May 13, 2012; Accepted date: July 30, 2012; Published date: August 01, 2012

Citation: Khalafallah A, Al-Barzan AM, Chan J, Sung MF, Bates G, et al. (2012) A Prospective Randomized Controlled Trial to Assess the Effect of Intravenous versus Oral Iron Therapy in the Treatment of Orthopaedic Preoperative Anaemia. J Blood Disorders Transf 3:127. doi:10.4172/2155-9864.1000127

Copyright: © 2012 Khalafallah A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Improving preoperative anaemia is associated with a better surgical outcome. There is lack of data regarding treatment of preoperative anaemia with intravenous versus oral iron.
Objective: Assessment of efficacy of oral iron sulphate versus a single intravenous iron polymaltose and
subsequent effect on perceived quality of life in both treatment groups.
Patients and methods: We conducted a prospective randomised controlled trial with iron therapy for the
treatment of Iron Deficiency Anaemia (IDA) patients who were undergoing elective joint arthroplasty. At a single institution, we recruited 44 patients who were randomized to a single intravenous iron polymaltose infusion (16/22) versus oral daily iron sulphate (17/22). Median age was 68 years (range, 45-91) with a male to female ratio of 14:19.
Results: After iron therapy, the immediate mean preoperative Hb was increased to 128 g/L (SD ± 11.05) in the IV iron group versus 118 g/L (SD ± 9.23) in the oral iron group (p=0.01) compared to 116 g/L (SD ± 8.46) in the control group (p=0.001). The average length of stay in the hospital for the IV iron group was 6 days (SD ± 2.51) compared to 8 days (SD ± 3.62) in the oral iron group and 8 days (SD ± 4.18) in the control group (p=0.04). Average transfused blood units were 1.5 units in the IV iron group versus 2 units in the oral iron group (p=0.09) and 2.4 units in the control group (p = 0.04). There was a significant improvement of the symptoms of anaemia (p=0.03) after treatment in the IV versus oral iron group with further improvement at 3 months follow-up (p=0.003).
Conclusion: Our data suggest that IV iron therapy is superior to oral iron in improving preoperative Hb
and hence overall outcome for patients with preoperative IDA. Further trials that aim to improve and optimize preoperative and postoperative Hb are warranted.

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