alexa A Prospective Study on Inflammatory Cytokines and Bone Metabolism Mediators in Patients Affected by Rheumatoid and Psoriatic Arthritis treated with Adalimumab
ISSN: 2167-7921

Journal of Arthritis
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Research Article

A Prospective Study on Inflammatory Cytokines and Bone Metabolism Mediators in Patients Affected by Rheumatoid and Psoriatic Arthritis treated with Adalimumab

Maria Sole Chimenti1*, Paola Conigliaro1, Maria Morello2, Rossella Zenobi2, Paola Triggianese1, Carlo Perricone3, Lucia Novelli1, Sergio Bernardini2 and Roberto Perricone1
1Rheumatology, Allergology and Clinical Immunology, Department of Medicina dei Sistemi, University of Rome “Tor Vergata”, Italy
2Department of Experimental Medicine and Surgery, University of Rome “Tor Vergata”, Italy
3Reumatologia, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Italy
Corresponding Author : Maria Sole Chimenti
Rheumatology, Allergology and Clinical Immunology
Medicina dei sistemi, University of Rome “Tor Vergata”
Viale Oxford, 81-00133–Rome, Italy
Tel: +39 06 20900967
Fax: +39 06 20900358
E-mail: [email protected] uniroma2.it
Received July 12, 2015; Accepted July 24, 2015; Published August 05, 2015
Citation: Chimenti MS, Conigliaro P, Morello M, Zenobi R, Triggianese P, et al. (2015) A Prospective Study on Inflammatory Cytokines and Bone Metabolism Mediators in Patients Affected by Rheumatoid and Psoriatic Arthritis treated with Adalimumab. J Arthritis 4:158. doi:10.4172/2167-7921.1000158
Copyright: © 2015 Chimenti MS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Rheumatoid (RA) and Psoriatic arthritis (PsA) are characterized by extensive synovitis resulting in bone destruction in both diseases and new bone formation in PsA. Objective: This prospective study analyzed interleukin (IL)-6, IL-17, IL-23, tumor necrosis factor (TNF)-α serum and synovial fluid (SF) levels and osteoprotegerin (OPG), bone-specific alkaline phosphatase (BAP) and D-vitamin (D-Vit) serum levels in RA and PsA patients before and after anti-TNF-α. Methods: 15 RA and 15 PsA patients with knee effusion and starting adalimumab (ADA) treatment were enrolled. Serum and SF from inflamed knee joint samples were obtained at baseline and after 24 weeks of treatment. Statistical analysis was performed using Graph Pad 5.0 statistical software. Results: In RA and PsA, SF IL-6, IL-17, and TNF-α were higher than serum levels while higher serum IL-23 was detected than in SF. Higher serum/SF IL-6, IL-23 and SF TNF-α were observed in RA than PsA, while serum IL-17 was higher in PsA than RA. Positive feedback among IL-6, IL-23, IL-17 and CRP and negative correlation between IL-17 and TNF-α in RA were found. In PsA, IL-23 correlated positively with IL-6. OPG correlated positively with ESR/CRP in RA and PsA. D-Vit correlated negatively with OPG and ESR in PsA. Higher BAP in RA than PsA and positive correlation with IL-6 in RA and with OPG in PsA were noticed. In PsA, IL-6 and OPG serum levels decreased significantly after 24 weeks ADA treatment. Conclusions: Distinct distribution of inflammatory cytokines and correlations with bone mediators were detected in RA and PsA. ADA affected inflammatory cytokines and bone mediators in PsA patients.

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