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ISSN: 2157-7536

Journal of Steroids & Hormonal Science
Open Access

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Research Article

A Proteomic Profile of Cervical Remodeling in Mice during Early and Late Pregnancy

John Schwabe1, Siobhan M Donnelly1, Subrina Jesmin2, Phyllis Leppert3 and Chishimba Nathan Mowa1,4*

1Appalachian State University, Department of Biology, Boone, NC, USA

2Tsukuba University, Department of Internal Medicine, Tsukuba, Japan

3Duke School of Medicine, Department of Obstetrics and Gynecology, Durham, NC, USA

4University of Johannesburg, Faculty of Health Sciences, Department of Anatomy and Physiology, Johannesburg, South Africa

*Corresponding Author:
Chishimba Nathan Mowa
Appalachian State University
Department of Biology
Rankin Science North Building N219
572 River Street, Boone, NC 28608, USA
Tel: +1-828-262 2676
Fax: +1-828-262 2127
E-mail: [email protected]

Received date: September 04, 2013; Accepted date: December 30, 2013; Published date: January 10, 2014

Citation: Schwabe J, Donnelly SM, Jesmin S, Leppert P, Mowa CN (2014) A Proteomic Profile of Cervical Remodeling in Mice during Early and Late Pregnancy. J Steroids Horm Sci 5:123. doi:10.4172/2157-7536.1000123

Copyright: © 2014 Schwabe J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objective: Decipher mechanisms that underlie cervical remodeling (CR) during pregnancy.
Design and population: Examine the proteomic profile of mice cervices in early and late pregnancy and verify data generated using Western Blot and real time PCR analysis. Main outcome measures: Identify signature proteins.
Results: In total, seventy three (73) signature proteins were identified and were found up regulated in pregnancy, namely proteins associated with: a) collagen presence and organization (4), notably biglycan and lumican, b) immune scavenging functions and c) cytoskeletal activity. These proteomic trends were verified through Western blot and real time PCR analysis.
Conclusion: These signature proteins and their expression profile collectively suggest a complex biological process involving extracellular matrix (ECM)- and immune`-associated factors. Based on these data, we propose that biglycan may provide the link between natural birth and inflammation-mediated pre-term birth.

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