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A Rare and Particular form of Goiter to Recognize | OMICS International | Abstract
ISSN: 2165-7920

Journal of Clinical Case Reports
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Case Report

A Rare and Particular form of Goiter to Recognize

Houda Ben Rejeb1, Emna Braham1*, Adel Marghli2, Ilhem Hergli1, Tarek Kilani2 and Faouzi El Mezni1
1Department of Pathology, Abderrahmen Mami Hospital, 2083, Ariana, Tunisia
2Department of Thoracic Surgery, Abderrahmen Mami Hospital, 2083, Ariana, Tunisia
Corresponding Author : Emna Braham
Department of Pathology, Abderrahmen Mami Hospital
2083, Ariana, Tunisia
E-mail: [email protected]
Received March 26, 2012; Accepted April 06, 2012; Published April 17, 2012
Citation: Rejeb HB, Braham E, Marghli A, Hergli I, Kilani T, et al. (2012) A Rare and Particular form of Goiter to Recognize. J Clinic Case Reports 2:127.doi:0.4172/2165-7920.1000127
Copyright: © 2012 Rejeb HB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Dyshormonogenetic goiter is a rare cause of congenital hypothyroidism occurring due to a lack of enzymes necessary for the synthesis of thyroid hormones. It is morphologically characterized by architectural and cellular pleomorphism that may mimic thyroid malignancy and cause difficulties in differential diagnosis. We report a new case occurring in a 37-year-old male with history of hypothyroidism since the age of 6 years treated by L-thyroxin. He developed a progressively slow growing multinodular goiter and consulted for recent dyspnea. Computed tomography scan showed a multinodular plunging goiter with compression of the trachea and vessels in the left side. A total thyroidectomy was performed. Gross examination revealed an enlarged and multinodular thyroid gland, presenting hemorrhagic changes in the larger nodules. Histologically, the features were consistent with dyshormonogenetic goiter. The literature on the histopathology of dyshormonogenetic goiter is reviewed and clues to avoid inappropriate overdiagnosis of malignancy are given.

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