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ISSN: 2165-7920

Journal of Clinical Case Reports
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Case Report

A Rare but Fatal Complication Probably due to Imatinib: Cerebral Edema

Ozgur Mehtap1, Elif Birtas Atesoglu1, Pinar Tarkun1, Abdullah Hacihanefioglu1*, Hakan Keski1 and Sehnaz Basaran2
1Medical Faculty, Department of Hematology, University of Kocaeli, Turkey
2Medical Faculty, Department of Neurology, University of Kocaeli, Turkey
Corresponding Author : Abdullah Hacihanefioglu
Faculty of Medicine, Department of Hematology
Kocaeli University, Umuttepe Campus
P.O.-41380, Kocaeli, Turkey
Tel: +90-262-3038238/7522
Fax: +90-262-3038003
E-mail: [email protected]
Received June 07, 2012; Accepted July 20, 2012; Published July 23, 2012
Citation: Mehtap O, Atesoglu EB, Tarkun P, Hacihanefioglu A, Keski H, et al. (2012) A Rare but Fatal Complication Probably due to Imatinib: Cerebral Edema. J Clin Case Rep 2:176. doi:10.4172/2165-7920.1000176
Copyright: © 2012 Mehtap O, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Imatinib mesylate is a tyrosine kinase inhibitor that strongly inhibits the tyrosine kinases like BCR-ABL1, KIT and PDGFRB and is used in the treatment of chronic myeloid leukemia. As well as its proven effectiveness its frequent side effects are also well known. Apart from its other side effects its commonly encountered side effect in daily clinical use is edema. Although the path-physiology of this process has not yet been well understood, its strong blocking action on PDGFRB is thought to be responsible. In this case report we are presenting a chronic myeloid leukemia patient with cerebral edema who unfortunately died. To our knowledge, she has been the third patient who was reported due to this complication of imatinib. As we could not estimate another cause we strongly deduced that the cerebral edema was due to imatinib.

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