A Rare Case of Focal Segmental Glomerulosclerosis in a Patient with Grade a Benign Thymoma: A Case Report and Review of the Literature
- *Corresponding Author:
- Prashan Buddhika
Registrar in Internal Medicine
Colombo South Teaching Hospital
Kalubowila, Sri Lanka
Tel: +94 11 2 763261
E-mail: [email protected]
Received date: March 17, 2016; Accepted date: May 19, 2016; Published date: May 25, 2016
Citation: Illeperuma PB, Jayanaga A (2016) A Rare Case of Focal Segmental Glomerulosclerosis in a Patient with Grade a Benign Thymoma: A Case Report and Review of the Literature. J Clin Case Rep 6: 794. doi:10.4172/2165-7920.1000794
Copyright: © 2016 Illeperuma PB et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Thymoma is a rare mediastinal tumour that is often (40%) accompanied by different paraneoplastic syndromes and glomerulonephritis is one of the recognized entities. Minimal change disease is the most common paraneoplastic glomerulonephritis associated with thymoma, followed by membranous nephropathy, focal segmental glomerulosclerosis, rapidly proliferative glomerulonephritis and lupus nephritis. Literature review illustrates that most of the thymoma associated nephropathy cases were reported in association with more malignant thymic tumors like WHO grade B and C tumours. Herein we report a rare case of focal segmental glomerulosclerosis in a patient with grade A benign thymoma, a combination which has never been reported previously. She had poor response to corticosteroids and died due to neutropenic sepsis following azathioprine therapy.