alexa A Rare Cause of Pigmentation Disorder; Tuberous Scleros
ISSN: 2376-0427

Dermatology and Dermatologic Diseases
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Previously: Journal of Pigmentary Disorders

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Review Article

A Rare Cause of Pigmentation Disorder; Tuberous Sclerosis Complex

Ragip Ismail Engin1and Atilla Cayir2*
1Region Training and Research Hospital, Department of Dermatology, Erzurum, Turkey
2Region Training and Research Hospital, Department of Pediatrics, Erzurum, Turkey
Corresponding Author : Atilla Cayir
Departments of Pediatrics
Regional Training and Research Hospital, Erzurum, Turkey
Tel: +905331382744
Fax: +04422325090
E-mail: [email protected]
Received: June 08, 2015 Accepted: August 08, 2015 Published: August 18, 2015
Citation: Engin RI and Cayir A (2015) A Rare Cause of Pigmentation Disorder; Tuberous Sclerosis Complex. Pigmentary Disorders 2:211. doi: 10.4172/2376-0427.1000211
Copyright: © 2015 Cayir A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Tuberous sclerosis complex is an autosomal dominant neurocutaneous disease principally characterized by the triad of mental retardation, adenoma sebaceum and epilepsy. It may affect all organs, but most commonly the skin, brain, heart, eyes and kidneys. The earliest finding, and the most common in the skin, consists of hypopigmented macules (ash leaf). In addition, numerous small hypopigmented macules (confetti-like macules) occur in the pretibial region. Shagreen patches, a form of collagenoma, may be seen in the lumbosacral region in half of patients. Skin findings also include angiofibromas, known as adenoma sebaceum, in the face and Koenen’s tumor. Other skin lesions include cafe-au-lait spots and molloscum fibrosum pendulum resembling acrochordon. We describe the skin findings in particular of tuberous sclerosis complex in the light of the current literature.


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