alexa <p>A Reduced Gray Matter Volume in Patients with Bipolar II Disorder in a Japanese Sample: A Comparison with Schizophrenia</p> | OMICS International| Abstract

ISSN 2472-1077

Bipolar Disorder: Open Access

  • Research Article   
  • Bipolar Disord 2016, Vol 2(2): 2
  • DOI: 10.4172/2472-1077.1000110

A Reduced Gray Matter Volume in Patients with Bipolar II Disorder in a Japanese Sample: A Comparison with Schizophrenia

Akeo Kurumaji1*, Michio Itasaka1, Akihito Uezato1, Kazuo Takiguchi1, Daisuke Jitoku1, Mizue Hobo1 and Kiyotaka Nemoto2
1Section of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
2Department of Neuropsychiatry, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
*Corresponding Author : Akeo Kurumaji, Section of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, 1-5-45 Yushima, Bunkyou-ku, Tokyo 113-8519, Japan, Tel: 03-5803-5242, Email: [email protected]

Received Date: Sep 29, 2016 / Accepted Date: Oct 07, 2016 / Published Date: Oct 14, 2016

Abstract

Objective: Neuroimaging studies of bipolar disorders have provided an insight into the pathophysiology, and have raised an issue of a shared change with schizophrenia and the normalizing effect of lithium on the alteration. Despite the classification of the bipolar disorders into the bipolar I disorder (BP-I) and bipolar II disorder (BP-II), the patients with BP-II have only been involved in a limited number of the neuroimaging studies. There is minimal information about the direct comparison between BP-II and schizophrenia.

Methods: All patients were diagnosed using DSM-5 criteria. A cross-sectional study was carried out to compare the regional brain volumes among the patients with BP-II taking lithium (BP-II-On, n=17) and not taking it (BP-II-Off, n=22), the patients with schizophrenia (n=35) and healthy controls (n=36). The MRI data were processed using Statistical Parametric Mapping 8 and the divided brain areas were defined by an automated anatomical labeling.

Results: A significant reduction in the gray matter volume of the frontal, temporal and limbic lobes was similarly observed in BP-II-off and schizophrenia patients when compared to the controls. The brain volume of BP-II-On had significantly decreased in the temporal lobe, but not in either the frontal or limbic lobe. The less pronounced reduction of BP-II-On was also observed in the sub-regions of the prefrontal and limbic cortices, such as the anterior cingulate cortex.

Conclusion: The present study suggests that there was a similarity in the distribution pattern of the decreased gray matter volume in the brain between BP-II and schizophrenia, placing an emphasis on the lithium effect that putatively normalized the abnormality in the anterior frontal and limbic brain areas of BP-II. However, further studies are required to replicate the results in a larger cohort and to confirm the lithium effect in a longitudinal study.

Keywords: Bipolar II disorder; Schizophrenia; Gray matter: SPM8; An atlas-based method; Lithium; Prefrontal cortex; Anterior cingulate cortex

Citation: Kurumaji A, Itasaka M, Uezato A, Takiguchi K, Jitoku D, et al. (2016) A Reduced Gray Matter Volume in Patients with Bipolar II Disorder in a Japanese Sample: A Comparison with Schizophrenia. Bipolar Disord 2: 110. Doi: 10.4172/2472-1077.1000110

Copyright: ©2016 Kurumaji A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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