alexa A Review of Biological and Pharmacological Actions of M

Journal of Pharmacological Reports
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Review Article

A Review of Biological and Pharmacological Actions of Melatonin: Oxidant and Prooxidant Properties

Mohammad Ali Eghbal1,2*, Aziz Eftekhari1-4, Elham Ahmadian1,2, Yadollah Azarmi1,2 and Alireza Parvizpur1,2
1Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2Pharmacology and Toxicology Department, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
3Students Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
4Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author : Mohammad Ali Eghbal
Department of Pharmacology and Toxicology
Faculty of Pharmacy, Tabriz University of Medical Sciences
51664-14766 Tabriz, Iran
Tel: +98 41 33344798
Fax: +98 41 33344798
E-mail: [email protected]
Received January 12, 2016; Accepted February 02, 2016; Published February 06, 2016
Citation:Eghbal MA, Eftekhari A, Ahmadian E, Azarmi Y, Parvizpur A (2016) A Review of Biological and Pharmacological Actions of Melatonin: Oxidant and Prooxidant Properties. J Pharma Reports 1:106. doi:10.4172/jpr.1000106
Copyright: © 2016 Eghbal MA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Melatonin as an indole amine exists in most of mammals and produced by various organs. It involved in circadian regulation of physiological and neuroendocrine function. Also it modulates diverse physiological functions such as sleep and sexual behavior. During the last decade, melatonin has been shown to possess potent free radical scavenger properties against reactive oxygen species (ROS). Moreover, by induction of the expression of antioxidant enzymes and reduction of the activation of pro-oxidant enzymes, melatonin indirectly could protect cells against a variety of free radical-related diseases. Besides, melatonin has been shown to promote the generation of ROS at pharmacological concentrations in in-vitro studies. Although melatonin could potentially be useful but safety, efficacy remains uncertain. In the present report, we review the studies which document the influence of melatonin on the various oxidative stress associated diseases .We also analyze the possible mechanisms by which melatonin induce ROS formation.

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