alexa A Review of Fatty Liver/NASH and Liver Cirrhosis: Genetics, Prevention, Nutritional, Behavioral Modification, Exercise, Pharmaceutical, Biophysics and Biotech Therapy
ISSN: 2167-0889

Journal of Liver
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Review Article

A Review of Fatty Liver/NASH and Liver Cirrhosis: Genetics, Prevention, Nutritional, Behavioral Modification, Exercise, Pharmaceutical, Biophysics and Biotech Therapy

Trent W.Nichols Jr*
Good Samaritan Gastroenterology Associates, Lebanon, USA
Corresponding Author : Trent W.Nichols Jr
Good Samaritan Gastroenterology Associates Lebanon, USA
Tel: (O) 765-775-2825, (C)717-479-1608, (H)717-633-5540
E-mail: twnicholpa@comcast.net
Received November 15, 2013; Accepted December 10, 2013; Published December 17, 2013
Citation: Nichols TW (2013) A Review of Fatty Liver/NASH and Liver Cirrhosis: Genetics, Prevention, Nutritional, Behavioral Modification, Exercise, Pharmaceutical, Biophysics and Biotech Therapy. J Liver 3: 144. doi: 10.4172/2167-0889.1000144
Copyright: © 2013 Nichols TW Jr. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

This article reviews the current factors concerning obesity, metabolic syndrome or DM2 and the accumulation of fat which can result in fatty liver or steatohepatitis (NAFLD) and its progression to non-alcoholic steatohepatitis (NASH) and cirrhosis. The pathophysiology is discussed as well as the current treatment and nutritional options of betaine, SAMe, phosphatidylcholine, silymarin with vitamin E and probiotics. Since obesity, metabolic syndrome and NAFLD/NASH are polygenic as well as epigenetic, the current nutritional, pharmaceutical and biotec solutions are fairly limited. Future options may include biophysical such as temperature control, light therapy ormelatonin and moderate magnetic field therapy capable of regulating over 2500 genes as well as novel can nabinoidagents and polyphenols.

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