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ISSN: 2155-9554

Journal of Clinical & Experimental Dermatology Research
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Research Article

A Review of Lupus Miliaris Disseminatus Faciei-Like Histopathologic Changes in 10 Cases

Kathryn Echols1*, Fiona Fang2 and James W. Patterson2,3

1Medical University of South Carolina, Department of Dermatology and Dermatologic Surgery, Charleston, South Carolina

2University of Virginia, Department of Dermatology, Charlottesville, Virginia

3University of Virginia, Department of Pathology, Charlottesville, Virginia

*Corresponding Author:
Kathryn F Echols
Medical University of South Carolina
Department of Dermatology and Dermatologic Surgery
135 Rutledge Avenue; MSC 578 Charleston
SC 29425, South Carolina
Tel: 843-792-6963
E-mail: [email protected]

Received date: May 19, 2014; Accepted date: June 28, 2014; Published date: July 05, 2014

Citation: Echols K, Fang F, Patterson JW (2014) A Review of Lupus Miliaris Disseminatus Faciei-Like Histopathologic Changes in 10 Cases. J Clin Exp Dermatol Res 5:223. doi:10.4172/2155-9554.1000223

Copyright: © 2014 Echols K. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Objective: To determine the clinical and histopathologic features of all lesions diagnosed as lupus miliaris disseminatus faciei via biopsy over the past 16 years at a single institution. Clinical features reviewed included age of patient, location and number of lesions, duration, description of primary lesion, size, and suspected clinical diagnosis or differential diagnosis. Histopathologic features reviewed included presence of caseation necrosis, depth of granuloma, presence of lymphocytic infiltrate, disruption of hair follicles, and presence of multinucleated giant cells.

Methods: The records of 10 patients (mean age, 50.4 years; range, 6 to 79 years) with characteristic histologic features of lupus miliaris disseminatus faciei were reviewed and the histopathologic findings and clinical features were analyzed. Formalin-fixed, paraffin-embedded specimens were examined by hematoxylin-eosin staining.

Results: The most common clinical appearance was a single papule located on the face. Two cases with solitary, extrafacial distributions were reported. All cases demonstrated epithelioid granulomas with a central area of caseation necrosis. The majority of granulomas were perifollicular in location and were comprised of histiocytes, lymphocytes, and multinucleated giant cells.

Conclusion: The 10 cases we report demonstrate the importance of recognizing the entity in solitary as well as extrafacial forms. Limiting the histologic diagnosis to fully developed lesions demonstrating epithelioid granulomas with caseation necrosis serves to clarify the diagnosis in the setting of diverse clinical presentations. Further information is needed to clarify the diagnosis, etiology, and pathogenesis of this disease, but an unusual host response to folliculitis or follicular injury likely plays a role in most cases.


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