A Review of Multiple Sclerosis as an Infectious Syndrome
Charles W Stratton*
Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
- *Corresponding Author:
- Charles W Stratton
Department of Pathology, Microbiology and Immunology
Room 4525-TVC, The Vanderbilt Clinic
Vanderbilt University Medical Center
1301 Medical Center Drive, Nashville
TN 37232, USA
E-mail: [email protected]
Received date: September 01, 2016; Accepted date: October 26, 2016; Published date: October 31, 2016
Citation: Stratton CW (2016) A Review of Multiple Sclerosis as an Infectious Syndrome. J Neurol Neurophysiol 7:400. doi:10.4172/2155-9562.1000400
Copyright: © 2016 Stratton CW. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Multiple sclerosis (MS) is a chronic neuroinflammatory disease of the central nervous system (CNS) that is generally considered to be an autoimmune myelitis of unknown etiology. Epidemiological studies suggest that infection may act as a trigger on a predisposing genetic background. A number of causative agents have been considered. This review will focus on the pathogenesis of MS and link this pathophysiology to infectious agents that have been implicated as possible co-factors. By doing so, MS will be viewed as an infectious syndrome that involves a CNS infection that results in a neurodegenerative process as well as an autoimmune disease. Early detection of infectious triggers could allow appropriate intervention and thus improved outcomes.