A Sequence Motif Associated with Intrinsic Mutation Hot-Spots in Human Cancers
Isar Nassiri, Esmaeel Azadian and Ali Masoudi-Nejad*
Laboratory of Systems Biology and Bioinformatics (LBB), Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
- *Corresponding Author:
- Ali Masoudi-Nejad
Laboratory of Systems Biology and Bioinformatics (LBB)
Institute of Biochemistry and Biophysics
University of Tehran Tehran, Iran
E-mail: [email protected]
Received date: July 24, 2013; Accepted date: September 04, 2013; Published date: September 06, 2013
Citation: Nassiri I, Azadian E, Masoudi-Nejad A (2013) A Sequence Motif Associated with Intrinsic Mutation Hot-Spots in Human Cancers. J Proteomics Bioinform 6:183-186. doi:10.4172/jpb.1000279
Copyright: © 2013 Nassiri I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Mutability varies significantly along nucleotide sequences, and mutations occur at higher frequencies at certain positions of a genome. The high rate of mutation in some regions is independent from the function and structure of corresponding regions in protein products. This raises the possibility of DNA sequence and cis-elements as causes of mutations. We used computational methods to examine the surrounding region of 20 mutation hotspots related to different human genetic disorders, and combinatorial patterns of gene mutations in cancers. We introduced A(C/G)AA(C/G)(A/T) as an associated sequence motif in fourteen hotspot of mutations in different cancers. These observations are support the correlation between DNA motifs with hotspots of mutation in cancer and promising marker for selection of suitable regions for genes mutation screening.