alexa A Speculative Role for Stromal Gastrin Signaling in Dev
ISSN: 2165-7092

Pancreatic Disorders & Therapy
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Review Article

A Speculative Role for Stromal Gastrin Signaling in Development and Dissemination of Pancreatic Ductal Adenocarcinoma

Gail L Matters1 and Gary A Clawson1,2*
1Department of Biochemistry and Molecular Biology, Hershey Medical Center, Pennsylvania State University, Hershey, PA, USA
2Gittlen Cancer Research Foundation and Departments of Pathology, Biochemistry and Molecular Biology, USA
Corresponding Author : Gary A Clawson
Gittlen Cancer Research Foundation
Hershey Medical Center, H059, C7768
500 University Drive, Hershey, PA 17033, USA
E-mail: [email protected]
Received February 08, 2013; Accepted April 05, 2013; Published April 07, 2013
Citation: Matters GL, Clawson GA (2013) A Speculative Role for Stromal Gastrin Signaling in Development and Dissemination of Pancreatic Ductal Adenocarcinoma.Pancreatic Dis Ther S4:003. doi:10.4172/2165-7092.S4-003
Copyright: © 2013 Matters GL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

The peptide growth factor gastrin and its receptor, the G-protein coupled cholecystokinin receptor type B (CCKBR), play an integral role in the growth and progression of pancreatic ductal adenocarcinoma (PDAC). Gastrin immunoreactivity is found in the fetal pancreas but its expression is not detected in normal pancreas after birth, except when it is re-expressed in malignant lesions.

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