A Stochastic Segmentation Model for Recurrent Copy Number Alteration Analysis
Haipeng Xing* and Ying Cai
Applied Mathematics and Statistics, State University of New York, Stony Brook, NY 11794, USA
- *Corresponding Author:
- Haipeng Xing
Applied Mathematics and Statistics
State University of New York
Stony Brook, NY 11794, USA
E-mail: [email protected]
Received date: February 06, 2015; Accepted date: May 11, 2015; Published date: May 18, 2015
Citation: Xing H, Cai Y (2015) A Stochastic Segmentation Model for Recurrent Copy Number Alteration Analysis. J Biom Biostat 6:221. doi: 10.4172/2155-6180.1000221
Copyright: © 2015 Xing H, et al. This is an open-access article distributed underthe terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are are credited.
Recurrent DNA copy number alterations (CNAs) are key genetic events in the study of human genetics and disease. Analysis of recurrent DNA CNA data often involves the inference of individual samples’ true signal levels and the crosssample recurrent regions at each location. We propose for the analysis of multiple samples CNA data a new stochastic segmentation model and an associated inference procedure that has attractive statistical and computational properties. An important feature of our model is that it yields explicit formulas for posterior probabilities of recurrence at each location, which can be used to estimate the recurrent regions directly. We propose an approximation method whose computational complexity is only linear in sequence length, which makes our model applicable to data of higher density. Simulation studies and analysis of an ovarian cancer dataset with 15 samples and a lung cancer dataset with 10 samples are conducted to illustrate the advantage of the proposed model.