alexa A Study to Investigate the Role of GULP/ CED 6 Gene in “Eat Me” Signaling in Cellular Efferocytosis and Immunosurveillance

Immunological Disorders & Immunotherapy
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Research Article

A Study to Investigate the Role of GULP/ CED 6 Gene in “Eat Me” Signaling in Cellular Efferocytosis and Immunosurveillance

Banerjee H*, Bazemore B, Barfield A, Crummity D, Krauss C, Payne G, Rousch J and Manglik V

Department of Natural Pharmacy and Health Sciences, Elizabeth City State University Campus, University of North Carolina, Elizabeth City, USA

*Corresponding Author:
Banerjee H
Department of Natural, Pharmacy and Health Sciences
Elizabeth City State University Campus
University of North Carolina, Elizabeth City, USA
E-mail: [email protected]

Received Date: November 05, 2016; Accepted Date: November 28, 2016; Published Date: November 30, 2016

Citation: Banerjee H, Bazemore B, Barfield A, Crummity D, Krauss C, et al. (2016) A Study to Investigate the Role of GULP/ CED 6 Gene in “Eat Me” Signaling in Cellular Efferocytosis and Immunosurveillance. Immunol Disord Immunother 1:109.

Copyright: © 2016 Banerjee H, et al. This is an open-access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

In this report, investigations were done to study human GULP/ CED 6 genes role in presenting cancer cells to scavenger cells. CED 6 SiRNA was used to knock out the gene in Astrocytoma (HTB-12) cell lines to study its effects on expression of various “eat me” signals on these cells including Phosphatidyl serine (PtdSer) expression, nitric oxide (NO) signaling and Leukotrine B4 (LTB4) expression and Caspase 3 activation. Investigations were done by fluorescence microscopy techniques, ELISA assay and colorimetric assays using a standard microplate reader and spectrophotometer. Initial results showed all the above mentioned “eat me” signals were significantly decreased in CED 6 knock out cell lines. Therefore CED 6 gene must have a role in cancer cell clearance, pathway involved in the cross talk between CED 6 and other genes in this process is a matter of farther investigation.

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