alexa A Sub-Chronic Exposure Study of Arsenic on Hematological Parameters, Liver Enzyme Activities, Histological Studies and Accumulation Pattern of Arsenic in Organs of Wistar Albino Rats
ISSN: 2157-7099

Journal of Cytology & Histology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

A Sub-Chronic Exposure Study of Arsenic on Hematological Parameters, Liver Enzyme Activities, Histological Studies and Accumulation Pattern of Arsenic in Organs of Wistar Albino Rats

Al-Forkan M1*, Islam S2, Akter R3, Shameen Alam S1, Khaleda L1, Rahman Z2 and Salma Chowdhury DU1

1Department of Genetic Engineering and Biotechnology, University of Chittagong, Bangladesh

2Department of Pathology, Chittagong Medical College; Chittagong, Bangladesh

3Bangladesh Council of Scientific & Industrial Research Laboratories, Chittagong, Bangladesh

*Corresponding Author:
Al-Forkan Md
Department of Genetic Engineering and Biotechnology
University of Chittagong, Chittagong- 4331, Bangladesh
Tel: +880-1819383213
Fax: + 88-031-2606014
E-mail: [email protected]

Received Date: Nov 23, 2015; Accepted Date: Feb 15, 2016; Published Date: Feb 26, 2016

Citation: Al-Forkan M, Islam S, Akter R, Shameen Alam S, Khaleda L, et al. (2016) A Sub-Chronic Exposure Study of Arsenic on Hematological Parameters, Liver Enzyme Activities, Histological Studies and Accumulation Pattern of Arsenic in Organs of Wistar Albino Rats. J Cytol Histol S5: 06. doi:10.4172/2157-7099.S5-006

Copyright: © 2016 Al-Forkan Md, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The aim of this study was to determine the hematological and biochemical changes occurred in the blood of arsenic-exposed Wistar albino rats during 90 days sodium-arsenite exposure study, and additionally to investigate the histological injury in the organs (liver, kidney, spleen and heart) of Wistar rats along with identifying the accumulation pattern of arsenic in those organs. Wistar rats received the following treatments: (1) distilled water; (2) arsenic (10 ppm); (3) arsenic (30 ppm) (4) arsenic (50 ppm). We found anemia, immunosuppression as well as significant increase in liver enzyme activity in the blood of arsenic intoxicated rats. Moreover, this toxic metalloid produced marked necrosis in liver and kidney of rats, whereas in heart mild muscle necrosis was observed. In case of spleen, enlarged white pulp was seen with marked hemorrhage and necrosis. Besides, we also have found that liver and spleen accrued more arsenic than kidney and heart. So, for better understanding of the toxic effects of arsenic the findings of our study in animal model might become useful which will also aid to develop effective drug against arsenic mediated toxic effects on human health.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords