A Survivor of Methyl Ethyl Ketone Peroxide(MEKP) Toxicity
Mohamed Salah Shirazy* and Akram Muhammed Fayed
Department of Critical Care Medicine, Faculty of Medicine, University of Alexandria
- *Corresponding Author:
- Mohamed Salah Shirazy
11 Atlas street El Asafra Alexandria, Egypt
Received date: May 11, 2015 Accepted date: June 22, 2015 Published date: June 28, 2015
Citation: Shirazy MS, Fayed AM (2015) A Survivor of Methyl Ethyl Ketone Peroxide (MEKP) Toxicity. J Clin Toxicol 5:257. doi: 10.4172/2161-0495.1000257
Copyright: © 2015, Shirazy SM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Methyl ethyl ketone peroxide (MEKP) is a widely used catalyst in the hardening of ester resins. It is highly hazardous, since it is a highly reactive oxidizing compound. Thus, it’s exposure results in chemical burns and release of free radicals. Previously reported cases of MEKP ingestion showed high morbidity and mortality as it caused severe metabolic acidosis, acute liver and renal failure, upper gastrointestinal ulceration, optic disc atrophy, myocardial damage, coagulopathy, and neurologic damage. A 42-year-old man accidentally ingested about 150 ml of MEKP 40% followed by ingestion of 100 ml olive oil. He was treated with stomach wash, free radical scavengers, and hemodialysis. Although he developed mild hematemesis, myocardial and hepatic impairment, coagulopathy, and papillitis, he neither developed renal impairment nor any gastrointestinal strictures after 4 weeks. Besides, his cardiac and hepatic functions, and coagulapthy were rapidly improved. Treatment with careful stomach wash, olive oil, free radical scavengers, and hemodialysis may be effective in reducing the morbidity and mortality of MEKP.