alexa A Systematic Approach to Preclinical Trials in Metastatic Breast Cancer
ISSN: 2167-7700

Chemotherapy: Open Access
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Short Communication

A Systematic Approach to Preclinical Trials in Metastatic Breast Cancer

Rashid OM1,2,3,*,Maurente D4, Takabe K5,6

1Holy Cross Hospital Michael and Dianne Bienes Comprehensive Cancer Center, 4725 North Federal Highway, Fort Lauderdale, FL 33308, USA

2Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA

3University of Miami Miller School of Medicine, 1600 NW 10th Ave, Miami, FL 33136, USA

4Florida Atlantic University Charles E. Schmidt College of Medicine, 777 Glades Road, Boca Raton, FL 33431,USA

5Virginia Commonwealth University School of Medicine and the Massey Cancer Center, Division of Surgical Oncology, Department of Surgery, Richmond, VA, USA

6Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA

*Corresponding Author:
Omar M Rashid
Holy Cross Hospital Michael and Dianne Bienes Comprehensive Cancer Center
4725 North Federal Highway, Fort Lauderdale
FL 33308, USA
Tel: 0019542677700
E-mail: [email protected]

Received date: August 12, 2015; Accepted date: May 25, 2016; Published date: May 30, 2016

Citation: Rashid OM, Maurente D, Takabe K (2016) A Systematic Approach to Preclinical Trials in Metastatic Breast Cancer. Chemo Open Access 5: 204. doi:10.4172/2167-7700.1000204

Copyright: © 2016 2016 Rashid OM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The process of developing new agents for therapy against breast cancer is inefficient and relies on animal models to screen for efficacy for preclinical studies. However, there has been limited validation of these models, despite the increasing costs in the rapidly growing era of personalized medicine and targeted therapy. Recently, there have been multiple studies which have critically evaluated animal models for breast cancer drug discovery. We recently reviewed the transgenic, xenograft, and syngeneic murine breast cancer models, the ectopic, orthotopic and intravenous methods of cell implantation, tumor gene expression profiles, as well as the ethics of animal experimentation, and we provide important information for investigators in this challenging field. Because of the complexities of treating breast cancer and the increasing costs of developing new agents, the choice of the appropriate murine model must carefully consider each model available, including the tumor gene expression profile. Such a critical approach to the in vivo portion of drug development will further increase the efficiency of breast cancer drug research and development.


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