alexa A Teenager Diagnosed as Lymphocytic Hypophysitis Associated with Systemic Lupus Erythematosus (SLE)
ISSN: 2155-9864

Journal of Blood Disorders & Transfusion
Open Access

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Case Report

A Teenager Diagnosed as Lymphocytic Hypophysitis Associated with Systemic Lupus Erythematosus (SLE)

Jing E1, Li Cao1, Hui Wang1, Li Bao1, Hong-Yan Luo1, Jing Li2 and Ya-Li Zheng1*

1Deptment of Nephrology in Ningxia People’s Hospital, Ningxia, Yinchuan, 750001, China

2Department of Pathology in Ningxia People’s Hospital, Ningxia, Yinchuan, 750001, China

*Corresponding Author:
Ya-Li Zheng
Department of Nephrology in Ningxia People’s Hospital
Ningxia, Yinchuan, 750001, China
Tel: 15825382806
E-mail: [email protected]

Received date: April 03, 2014; Accepted date: April 22, 2014; Published date: April 28, 2014

Citation: Jing E, Li Cao, Hui Wang, Li Bao, Hong-Yan Luo, et al. (2014) A Teenager Diagnosed as Lymphocytic Hypophysitis Associated with Systemic Lupus Erythematosus (SLE). J Blood Disord Transfus 5:221. doi: 10.4172/2155-9864.1000221

Copyright: © 2014 Jing E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



A 15-year-old female was admitted to our hospital with intermittent fever, cough and sputum for one week, and diagnosed as pneumonia. Because of no clinic remission with antibiotic and antiviral treatment for one week and following with facial erythema, severe anemia, and neutropenia, appropriate screening laboratory examinations showed severe lower complements (C3, C4) and positives autoantibody such as ANA, ds DNA, Anti-Sm etc, Therefore, SLE was diagnosed with muti-organs involved including lungs, blood, liver, kidney, medical peritonitis, and central nervous system presented as irritable and moody. Because the patient complained of dizziness, fatigue, anorexia, hands trembling and showed a very indifferent mood, endocrinological tests were took. The results revealed very low levels of sex hormones, thyroid hormones and serum cortisol, and manifested as hypopituitarism. Magnetic resonance imaging (MRI) of pituitary region demonstrated a mild enlargement of the pituitary stalk. SLE associated with Lymphocytic hypophysitis (LYH) was suspected. And the clinical symptoms and laboratory tests were ameliorated after glucocorticoid treatment (involve twice methylprednisolone (MPIV) pulse therapy and oral 40 mg/d of MPIV) combined with cyclophosphamide therapy. Although, LYH associated with SLE have been reported, a 15-year teenager, as seen in this case, is a rare first presentation of SLE.


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