alexa A Therapeutic Answer for The Controversy of Insulin Cardio-Protection Among Dysglycemic Patients
ISSN: 2327-5146

General Medicine: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

A Therapeutic Answer for The Controversy of Insulin Cardio-Protection Among Dysglycemic Patients

Abdullah M. Nasrat1,*, Randa M. Nasrat2 and Mohammad M. Nasrat2
1Department of Surgery, Balghsoon Clinic, Jeddah, KSA
2Department of Internal Medicine, Helwan General Hospital, Helwan, Egypt
Corresponding Author : Abdullah M. Nasrat
Department of Surgery, Balghsoon Clinic
Jeddah, KSA, P.O. Box 52611, Jed. 21573
Tel: + 966 (012) 667 3645
Fax: + 966 (012) 667 3645
E-mail: [email protected]
Received:Oct 23, 2015; Accepted: Dec 26, 2015; Published: Dec 31, 2015
Citation: Nasrat AM, Nasrat RM , Nasrat MM (2015) A Therapeutic Answer for the Controversy of Insulin Cardio-protection among Dysglycemic Patients. Gen Med (Los Angel) 3:216. doi:10.4172/2327-5146.1000216
Copyright: © 2015 Nasrat AM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at Pubmed, Scholar Google
 

Abstract

Ghrelin and leptin are peptide hormones which, working antagonistically, regulate the energy balance of the body. Abnormal concentrations of these hormones are observed in the course of gastrointestinal diseases, where the clinical picture is characterized by nutritional disorders. Approximately 70% of patients with cystic fibrosis have body weight deficiency due to exocrine pancreatic insufficiency, respiratory failure, and secondary circulatory disorders as well as eating disorders. The aim of the study was to evaluate the levels of ghrelin and leptin in the blood serum of patients diagnosed with cystic fibrosis, in relation to their nutritional status and function of liver cells. Patients and methods: The study group consisted of 34 patients, 17 girls (50%) and 17 boys (50%), aged from 3 months to 18 years (mean age 4.5 years) who were diagnosed with cystic fibrosis on the basis of screening and/ or diagnostic tests. The analysis included the nutritional status (body weight and height, BMI), CFTR gene mutation, assessment of the exocrine pancreas function (albumin and glucose concentration in the blood serum, acid steatocrit in stool), abnormal lipid metabolism (cholesterol and triglyceride levels in blood serum), as well as liver cell function parameters and cholestasis (serum activity amino-transpherase, gamma-glutamyl transpeptidase, concentration of bile acids, coagulation parameters). In all children, serum ghrelin and leptin levels were measured by means of an immunoenzymatic test, using reagents from DRG Instruments. The results were statistically analyzed. Results: Serum ghrelin levels were significantly lower in the youngest patients (<1 year of age) compared with older age groups. Ghrelin concentration was significantly lower in patients with salt wasting syndrome (p<0.05). The statistically lower serum leptin levels were observed in patients with growth deficiency and increased parameters of cholestasis, particularly in the youngest age group. Conclusion: Ghrelin and leptin levels in children with cystic fibrosis correlate with the nutritional status and can be an early marker of exocrine pancreatic insufficiency.

The study aimed to illustrate the cardio-protective effect of blood-let out cupping therapy in dysglycemia. The controversy of insulin cardio-protection among dysglycemic patients is a confusing challenge. Glucose-insulin disproportion is a major reason for accumulation of acidic metabolites in the body leading to the current controversy about insulin role in cardio-protection. The micro-capillary dysfunction, the improper tissue perfusion with blood and the accumulation of acidic metabolites in the myocardium are leading to each other and could contribute to progression into major cardiac events. Withdrawal of these metabolites could disturb this ischemic vicious circle and offer the answer for the controversy of insulin cardio-protection among dysglycemic patients. Suction in cupping therapy works specifically on the blood trapped within the tissues together with the acidic metabolites which are believed to be functionally obliged to it. Skin scratching with the action of repeated suction delivers nitric oxide to the area which is a potent cardio protectant in health and disease.

Seven diabetic patients on insulin with recurrent moderate chest tightness due to variable grades of myocardial ischemia refused coronary catheterization. Therefore; a session of basic cupping therapy on the upper back and front of the chest was advised and employed for them.

Dramatic symptomatic relief and clinical recovery was documented in six patients. They were followed up for 18 months without any further cardiac issues.

On conclusion; cupping therapy in this way becomes a maneuver that could lead to correction of ischemic myocardial situations, and the tissues interstitial space therefore constitutes the intelligent yard where cupping exerts its biological talents.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords