A Useful Microsoft Excel Add-in Program for Pharmacokinetic Analysis
Baojian Wu* and Ming Hu
Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, 1441 Moursund Street, Houston, TX 77030, USA
- *Corresponding Author:
- Baojian Wu
1441 Moursund Street
Department of Pharmacological and Pharmaceutical Sciences
College of Pharmacy, University of Houston
Houston, TX77030, USA
E-mail: [email protected]
Received date: October 19, 2011; Accepted date: November 10, 2011; Published date: November 12, 2011
Citation: Wu B, Hu M (2011) A Useful Microsoft Excel Add-in Program for Pharmacokinetic Analysis. Pharm Anal Acta S11:002. doi: 10.4172/2153-2435.S11-002
Copyright: © 2011 Wu B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The aim of this study is to explore the possibility and versatility of Microsoft Excel in handling pharmacokinetic analysis (including model composing, simulation, and parameter estimation). We have developed the first version of an in-house pharmacokinetic tool XlSimEst, coded in Visual Basic for Application (VBA), which can be used for pharmacokinetic modeling and simulation with user-tailored models consisting of a system of differential equations. The special features of the program are: (1) pharmacokinetic models can be open and saved as ordinary text files, thus the model files can be created and edited using any text editor; (2) a quicker interface to perform simulation studies; (3) capable of a standard error estimation for fitted parameters; and (4) a simple interface for generating concentration-time plots.