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A Validated Time of Flight Mass Spectrometry for Quantitative Determination of Amantadine Hydrochloride and Memantine Hydrochloride | OMICS International | Abstract
ISSN : 2153-2435

Pharmaceutica Analytica Acta
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Research Article

A Validated Time of Flight Mass Spectrometry for Quantitative Determination of Amantadine Hydrochloride and Memantine Hydrochloride

Nahla Nour Salama1*, Shudong Wang2 and Elham Taha1

1Department of Pharmaceutical Chemistry, National Organization for Drug Control and Research (NODCAR), Egypt

2School of Pharmacy and Centre for Biomolecular Sciences, University of Nottingham, University Park, NG7 2RD, UK

*Corresponding Author:
Nahla Nour Salama
Department of Pharmaceutical Chemistry
National Organization for Drug Control and Research (NODCAR)
6-Abu Hazem Street, Pyramids Ave. P.O. Box 29, 35521 Giza, Egypt
Tel: +2-023-585-1299
E-mail: [email protected]

Received date: October 05, 2012; Accepted date: October 17, 2012; Published date: October 22, 2012

Citation: Salama NN, Wang S, Taha E (2012) A Validated Time of Flight Mass Spectrometry for Quantitative Determination of Amantadine Hydrochloride and Memantine Hydrochloride. Pharmaceut Anal Acta 3:172. doi: 10.4172/2153-2435.1000172

Copyright: © 2012 Salama NN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Introduction: Time of flight mass spectrometry was developed and validated for quantitative determination of amantadine and memantine in drug substances and products. Materials and methods: The method was based on time of flight electron spray ionization mass spectrometry technique without preliminary chromatographic separation and made use of memantine as internal standard of amantadine, which is used as internal standard of memantine. Results and conclusion: A linear relationship between drug concentrations and peak intensity ratios of ions of the analyzed substances is established in range of 23.80-2380.00 ng mL-1 for amantadine and memantine (r=> 0.998, n=6). The method is robust and reproducible with intra-and inter-assay precision (RSD % < 2.0%). The quantification limit was 23.8 ng mL-1 for both drugs. The described method has advantages over the reported methods as the assay was completed in less than 2 min with high accuracy and selectivity.

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