alexa Aberrant Activity of TAK1 is Associated with Retinal Pathology
ISSN: 2157-7099

Journal of Cytology & Histology
Open Access

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Research Article

Aberrant Activity of TAK1 is Associated with Retinal Pathology

Dvashi Z1, Rosner M2, Stein R1, Ziv H2, Barshack I3 and Pollack A1*

1Department of Ophthalmology, Kaplan Medical Center, Hadassah-Hebrew University of Jerusalem, Rehovot, Israel

2Department of Ophthalmology, Goldschleger Eye Research Institute, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel

3Department of Ophthalmology, Institute of Pathology, Sheba Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel Hashomer, Israel

*Corresponding Author:
Pollack A
Department of Ophthalmology, Kaplan Medical Center
Hadassah-Hebrew University of Jerusalem, Rehovot, Israel
[email protected]

Received Date: December 10, 2015; Accepted Date: February 12, 2016; Published Date: February 15, 2016

Citation: Dvashi Z, Rosner M, Stein R, Ziv H, Pollack A et al (2016) Aberrant Activity of TAK1 is Associated with Retinal Pathology. J Cytol HistolS5:007. doi:10.4172/2157-7099.S5-007

Copyright: © 2016 Pollack A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Transforming growth factor-β-activated kinase-1 (TAK1) is a mitogen activated protein kinase kinase kinase that is involved in diverse biological roles across species. Functioning downstream of TGF-β, TAK1 mediates the activation of the c-Jun N-terminal kinase (JNK) signaling pathway, serves as the target of pro-inflammatory cytokines, such as TNF-α, mediates NF-κβ activation, and plays a role in Wnt signaling in mesenchymal stem cells. Still, the expression of TAK1 in the retina has not been defined. In our study, pathological and immunohistochemical assessments indicate a link between retinal pathology and TAK1 phosphorylation. We observed similar TAK1 expression both in non-obvious and obvious retinal pathologies. However, the phosphorylated form of TAK1 in the segments of retina with obvious pathology was hardly detected compared to its expression in the segments with non-obvious pathology. This finding indicates, for the first time, a possible involvement of TAK1 in human retinal pathologies. Better understanding the expression pattern of TAK1 may serve as a new therapeutic avenue for retinal pathologies.


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