alexa Aberrant DNA Methylation in P1 Promoter Region of Tp53 Gene in Acute Leukemia
ISSN: 2329-6917

Journal of Leukemia
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Research Article

Aberrant DNA Methylation in P1 Promoter Region of Tp53 Gene in Acute Leukemia

Yong-Jiang Zheng1*, Fang Guo2, Yong Zou3 and Wu Jun4

1Department of Hematology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China

2Department of Obstetrics and Gynecology, Guangzhou Women and Children Medical Center Affiliated to Guangzhou Medical University, Guangzhou, P.R. China

3Department of Blood Transfusion, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China

4School of Engineering, Sun Yat-sen University, Guangzhou, P.R. China

*Corresponding Author:
Yong-Jiang Zheng
Department of Hematology
The Third Affiliated Hospital of Sun Yat-sen University
Guangzhou, P.R. China
Tel: +86 20 8411 2828
E-mail: zouyong0205@163.com

Received date: February 21, 2017; Accepted date: March 17, 2017; Published date: March 25, 2017

Citation: Zheng YJ, Guo F, Zou Y, Jun W (2017) Aberrant DNA Methylation in P1 Promoter Region of Tp53 Gene in Acute Leukemia. J Leuk 5:227. doi: 10.4172/2329-6917.1000227

Copyright: © 2017 Zheng YJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The present study was undertaken to investigate the aberrant DNA ethymlation in P1 promoter region of p53 gene in acute leukemia patients. The aberrant DNA methylation of Tp53 gene in fresh leukemia cells obtained from 31 newly diagnosed patients as well as monocyte leukemia U937 cells were detected by using polymerase chain reaction (PCR). The results revealed that aberrant DNA methylation in P1 promoter region of Tp53 was detectable in 12 cases of 31 leukemia patients (38.7%) as well as in U937 cells, while no aberrant DNA methylation of this gene was detected in normal control group (11 healthy volunteers), indicating that there was significant difference between acute leukemia patients and healthy donors (P=0.0183, Fisher’s exact test). Furthermore, no significant difference was found in acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL) patients (35.2% vs 42.8%, P=0.7241, Fisher’s exact test). Our results, for the first time to our knowledge, provide laboratory evidence that aberrant DNA methylation in P1 promoter region of Tp53 gene is an common phenomenon in both AML and ALL patients, and that the significance of this special DNA methylation in acute leukemia needs further and profound investigation.

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