alexa Aberrant Hypomethylated KRAS and RASGRF2 as a Candidate Biomarker of Low Level Benzene Hematotoxicity

Journal of Molecular Biomarkers & Diagnosis
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Research Article

Aberrant Hypomethylated KRAS and RASGRF2 as a Candidate Biomarker of Low Level Benzene Hematotoxicity

Jing Yang1,2#, Wenlin Bai1,2#, Zhongxin Xiao3#, Yujiao Chen1,2, Li Chen1,2, Lefeng Zhang1,2, Junxiang Ma1,2, Lin Tian1,2 and Ai Gao1,2*

1Department of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing 100069, P.R.China

2Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, P.R.China

3Center of Medical Experiment and Analysis, Capital Medical University, Beijing 100069, P.R.China

#These authors contributed equally to this work

*Corresponding Author:
Ai Gao
Department of Occupational Health and Environmental Health
School of Public Health
Capital Medical Universit
Beijing China, 100069, P.R.China
Tel: 86-10-83911774
Fax: 86-10-83911506
E-mail:[email protected]

Received Date: September 09, 2014;Accepted Date: September 25, 2014; Published Date: September 27, 2014

Citation: Yang J, Bai W, Xiao Z, Chen Y, Chen L, et al. (2014) Aberrant Hypomethylated KRAS and RASGRF2 as a Candidate Biomarker of Low Level Benzene Hematotoxicity. J Mol Biomark Diagn 5:195. doi:10.4172/2155-9929.1000195

Copyright: 2014 Yang J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited



Benzene is an important industrial chemical and an environmental contaminant. The mechanisms of low level benzene-induced hematotoxicity are unresolved. Aberrant DNA methylation, which may lead to genomic instability and the altered gene expression, is frequently observed in hematological cancers. The purpose of the present study was to conduct a genome-wide investigation to examine comprehensively whether low level benzene induces DNA methylation alteration in the benzene-exposed workers. Infinium 450K methylation array was used to compare methylation levels of the low level benzene-exposed individuals and health controls and the differentially expressed DNA methylation pattern critical for benzene hematotoxicity were screened. Signal net analysis showed that two key hypomethylated KRAS and RASGRF2 associated with low level benzene exposure were identified. Further, the hypomethylated RASGRF2 gene played central roles through regulation of Rho protein, MAPK, small GTPase mediated signal transduction. While the hypomethylated KRAS gene played important roles through small GTPase, Ras protein, MAPK cascade, Gap junction, Axon guidance, Tight junction, GnRH, T cell receptor signaling pathway, Acute myeloid leukemia, B cell receptor signaling pathway, Chronic myeloid leukemia, ErbB signaling pathway. Our preliminary study indicated that aberrant hypomethylated KRAS and RASGRF2 might be a potential methylated biomarker of low level benzene hematotoxicity.

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