Aberrations in Angiogenic Signaling and MYC Amplifications are Distinguishing Features of AngiosarcomaVittal Kurisetty Brad A Bryan*
Department of Biomedical Sciences, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas, USA
- *Corresponding Author:
- Brad A. Bryan
Department of Biomedical Sciences
Paul L. Foster School of Medicine
Texas Tech University Health Sciences Center
5001 El Paso Drive, MSB1 Room 2111
El Paso, Texas 79905 USA
E-mail: [email protected]
Received February 15, 2013; Accepted April 05, 2013; Published April 08, 2013
Citation: Kurisetty V, Bryan BA (2013) Aberrations in Angiogenic Signaling and MYC Amplifications are Distinguishing Features of Angiosarcoma. Angiol 1:102. doi: 10.4172/2329-9495.1000102
Copyright: © 2013 Kurisetty V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Angiosarcomas are very aggressive, rare malignant tumors that originate from vascular or lymphatic vessels and primarily occur following chemical exposure or radiation therapy. Tumor response to either chemotherapy, radiation, or novel anti-angiogenic therapeutics is very low, and because little is known regarding the aberrant signaling that controls these tumors, personalized treatment options for many of these patients are lacking. In this review, we summarize several recent findings regarding the genomics of angiosarcomas, including new discoveries regarding aberrant angiogenic signaling and Myc amplification as key features of this tumor type.