alexa Abnormal Long-Term Episodic Memory Profiles in Multiple Sclerosis? | OMICS International | Abstract
ISSN: 2376-0389

Journal of Multiple Sclerosis
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Research Article

Abnormal Long-Term Episodic Memory Profiles in Multiple Sclerosis?

Saenz Amaya1,2, Bakchine Serge1,2,3, Stepanov Igor4, Omigie Diana2,5,6,7, and Ehrlé Nathalie1,2,3*

1Hôpital Maison-Blanche, Service de Neurologie, France

2Equipe de Neuropsychologie et Cognition auditive, Laboratoire de Neurosciences Fonctionnelles et Pathologies EA 4559, Université de Lille-Nord de France, France

3CMRR de Champagne-Ardenne, Reims, France

4Department of Neuropharmacology, Institute for Experimental Medicine, 12 Acad. Pavlov Street, St. Petersburg, 197376, Russia

5Hôpital de la Pitié-Salpêtrière, Paris, France. Phone of the department of Neurology

6Centre de Neuroimagerie de Recherche (CENIR), Paris, France

7Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière (ICM), UPMC - UMR 7225 CNRS - UMRS 975 INSERM, Paris, France

Corresponding Author:
Nathalie Ehrlé
Hôpital Maison-Blanche (Service de neurologie) 45
rue Cognacq-Jay 51092 Reims Cedex France
Tel: (00 33) 3 26 78 39 64
Fax: (00 33) 326784319
E-mail: [email protected]

Received date: April 09, 2014; Accepted date: May 22, 2014; Published date: May 26, 2014

Citation: Amaya S, Serge B, Igor S, Diana O, and Nathalie E (2014) Abnormal Long-Term Episodic Memory Profiles in Multiple Sclerosis?. J Mult Scler 1:105. doi:10.4172/2376-0389.1000105

Copyright: © 2014 Ehrlé N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Objective: Various verbal episodic memory impairments have been demonstrated in multiple sclerosis (MS), including encoding, retrieval and storage processes. Our clinical experiment suggests that a subset of MS patients may show another pattern with a distinctive evolution of performances after a 20 minutes delay (short-delay versus long-delay free recall).

Methods: The current study assessed performances on the California Verbal Learning Test (CVLT) in MS with a special focus on evolution after delay to identify a subgroup of patients who may show a significant spontaneous improvement of long-delay free recall in comparison with short-delay free recall. Data from 52 MS patients were compared with those from 32 controls. Group analyses were conducted on classical scores. Individual MS performances were also analyzed, according to confidence intervals calculated using control data.

Results: From individual analysis, memory comorbidities were frequently observed in a MS patient (17% of MS patients had only one impaired score, 17% had two or three scores, 27% had four or five scores and 38% had six or more). Regarding the evolution after delay, three profiles were highlighted: two classical (stable and worsening, i.e. storage deficit) and a third showing a significant degree of improvement. The improvement was significantly correlated with processing speed, primacy effect and sensitivity to retroactive interference only in this third MS subgroup. This benefit from delay was not related to the effect of semantic clustering.

Conclusion: The current study suggests that a subgroup of MS patients might present a previously unreported abnormal long-term memory profile, in which an impaired short-term performance contrasts with a significant spontaneous improvement with delay. Previous studies have demonstrated the relevance of spaced learning in MS rehabilitation. If our results are corroborated in a larger sample, the CVLT may help to select patients that are likely to benefit from this temporal memory care.


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