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ISSN: 2155-6105

Journal of Addiction Research & Therapy
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Letter to Editor

Abnormalities in Ipsilateral Silent Period in the High-Risk for Alcohol Dependence: A TMS Study

Kesavan Muralidharan*, Ganesan Venkatasubramanian, Pramod K Pal and Vivek Benegal

Department of Psychiatry, National Institute of Mental Health and Neuro Sciences [NIMHANS], Bangalore, India

*Corresponding Author:
Dr. Kesavan Muralidharan
Associate Professor, Department of Psychiatry
National Institute of Mental Health and Neuro Sciences [NIMHANS] Bangalore-560029, India
Tel: 00 91 80 26995252
Fax: 00 91 80 26564830/26562121
E-mail: [email protected]

Received July 16, 2012; Accepted July 27, 2012; Published August 02, 2012

Citation: Muralidharan K, Venkatasubramanian G, Pal PK, Benegal V (2012) Abnormalities in Ipsilateral Silent Period in the High-Risk for Alcohol Dependence: A TMS Study. J Addict Res Ther 3:129. doi:10.4172/2155-6105.1000129

Copyright: © 2012 Muralidharan K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Central Nervous System (CNS) disinhibition has been reported to underlie the vulnerability to alcohol dependence (AD) in individuals with a high-family loading of AD [1]. Maturational lag and defective myelination of particular brain regions, including the corpus callosum(CC), have been reported in these individuals [2]. Morphometric studies reported significantly smaller total CC, genu and isthmus areas in these individuals after controlling for age and intracranial area [3].

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