A Liver Index and its Relationship to Indices of HCC AggressivenessBrian I Carr1*, Vito Guerra2, Edoardo G Giannini3, Fabio Farinati4, Francesca Ciccarese5, Gian Ludovico Rapaccini6, Maria Di Marco7, Luisa Benvegnù8, Marco Zoli9, Franco Borzio10, Eugenio Caturelli11, Alberto Masotto12 and Franco Trevisani13
- Corresponding Author:
- Brian I Carr, MD
Visiting Professor, Izmir Biomedicine and Genome Center
Dokuz Eylul University, Izmir, Turkey and Dean
Lusaka Apex Medical University, Lusaka, Zambia
Tel: 1 412 980 4518
E-mail: [email protected]
Received Date: August 01, 2016; Accepted Date: August 31, 2016; Published Date: September 05, 2016
Citation: Carr BI, Guerra V, Giannini EG, Farinati F, Ciccarese F, et al. (2016) A Liver Index and its Relationship to Indices of HCC Aggressiveness. J Integr Oncol 5:178. doi:10.4172/2329-6771.1000178
Copyright: © 2016 Carr BI et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A Hepatocellular (HCC) Aggressiveness Index was recently constructed, consisting of the sum of the scores for the 4 clinical parameters of maximum tumor size, multifocality, presence of portal vein thrombus and blood alphafetoprotein levels. It was observed that there was an association with several liver function tests. We have now formed a Liver Index from the 4 liver parameters with the highest hazard ratios with respect to HCC aggressiveness, namely: blood total bilirubin, gamma glutamyl transpeptidase (GGTP), albumin and platelet levels (cirrhosis surrogate). We found that the scores for the Liver Index related significantly to survival, but also to the Aggressiveness Index and to its individual HCC components as well as showing significant trends with the components. These results support the hypothesis that liver function is not only an important prognostic factor in HCC patients, but may also be involved in HCC biology and aggressiveness. Blood albumin, GGTP, albumin and platelet levels were used to create a Liver Index that related significantly to parameters of HCC aggressiveness.