Acceleration of Hair Growth Rate by Topical Liposomal Cepharanthine in Male Androgenetic Alopecia
Inui S, Tohyama C and Itami S*
Department of Regenerative Dermatology, Osaka University School of Medicine, Osaka, Japan
- *Corresponding Author:
- Itami S
Department of Regenerative Dermatology
Osaka University, Osaka, Japan
E-mail: [email protected]
Received date: September 10, 2016; Accepted date: October 05, 2016; Published date: October 13, 2016
Citation: Inui S, Tohyama C, Itami S (2016) Acceleration of Hair Growth Rate by Topical Liposomal Cepharanthine in Male Androgenetic Alopecia. Hair Ther Transplant 6:145. doi: 10.4172/2167-0951.1000145
Copyright: © 2016 Inui S. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Because we previously found that cepharanthine (CEP) induces production of IGF-I, one of anagen inducers, from dermal papilla cells, we investigated clinical effect of topical lipoid CEP (lipo-CEP) on hair growth of male androgenetic alopecia (AGA). Twenty-three males with early AGA applied 0.1% lipo-CEP lotion once a day on the vertex area for 6 months. As a result, hair growth rate was significantly accelerated from 0.243 to 0.281 mm/day (p<0.01). Likewise, hair density and thickness increased but the changes were not statistically significant (p<0.1). From these results, lipo-CEP lotion can stimulate hair growth mainly through accelerating growth rate, representing a hopeful reagent for treating AGA.