alexa Acetamiprid Induces Toxicity in Mice under Experimental Conditions with Prominent Effect on the Hematobiochemical Parameters
ISSN: 2157-7609

Journal of Drug Metabolism & Toxicology
Open Access

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Research Article

Acetamiprid Induces Toxicity in Mice under Experimental Conditions with Prominent Effect on the Hematobiochemical Parameters

Tej Bahadur Singh1, Sunit Kumar Mukhopadhayay1*, Tapas Kumar Sar2 and Subha Ganguly3*

1Department of Veterinary Pathology, Faculty of Veterinary & Animal Sciences, West Bengal University of Animal and Fishery Sciences, Kolkata 700 037, WB, India

2Department of Veterinary Pharmacology & Toxicology, Faculty of Veterinary & Animal Sciences, West Bengal University of Animal and Fishery Sciences, Kolkata 700 037, WB, India

3AICRP-PHT (ICAR), Department of Fish Processing Technology, Faculty of Fishery Sciences, West Bengal University of Animal and Fishery Sciences, Kolkata 700 094, WB, India

*Corresponding Authors:
Sunit Kumar Mukhopadhayay
Department of Veterinary Pharmacology & Toxicology
Faculty of Veterinary & Animal Sciences
West Bengal University of Animal and Fishery Sciences, Kolkata 700 037, WB, India
E-mail: [email protected]
 
Subha Ganguly
AICRP-PHT (ICAR), Department of Fish Processing Technology
Faculty of Fishery Sciences, West Bengal University of Animal and Fishery Sciences
Kolkata 700 094, WB, India
E-mail: [email protected]

Received date: November 21, 2012; Accepted date: November 26, 2012; Published date: November 30, 2012

Citation: Singh TB, Mukhopadhayay SK, Sar TK, Ganguly S (2012) Acetamiprid Induces Toxicity in Mice under Experimental Conditions with Prominent Effect on the Hematobiochemical Parameters. J Drug Metab Toxicol 3:134. doi: 10.4172/2157- 7609.1000134

Copyright: © 2012 Singh TB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The present study was carried out to assess the toxicological effect of acetamiprid, an insecticide of neonicotinoid group on clinical and serum hematobiochemical parameters of mice. The experimental animals were divided into four different groups of equal number of animals and the first group was considered as Control. It was found that acetamiprid administered @ 40 mg/kg body weight per day (1/5th of LD% value) for a period of 28 days induces prominent toxic symptoms along with hematological and biochemical effect in mice. Acetamiprid induced mice showed decrease in body weight and clinical symptoms like respiratory depression, sitting in the corner, diarrhea, depression, dullness etc. are observed at the different dose levels. Test mice administered with acetamiprid showed significant decrease in overall hematological profile. In the present study, it was found that acetamiprid @ 10 mg/
kg body weight (1/20th of LD50 value) did not produce significant changes in hematological and biochemical values. So, it was considered that experimental dose of 10 mg/kg to be non-toxic and 40 mg/kg body weight to be the toxic dose of acetamiprid in mice.

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