alexa Acidity of Microenvironment as a Further Driver of Tumor Metabolic Reprogramming
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

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Review Article

Acidity of Microenvironment as a Further Driver of Tumor Metabolic Reprogramming

Silvia Peppicelli, Elena Andreucci, Jessica Ruzzolini, Francesca Margheri, Anna Laurenzana, Francesca Bianchini and Lido Calorini*

Department of Experimental and Clinical Biomedical Sciences, University of Florence, Istituto Toscano Tumori, Florence, Italy

*Corresponding Author:
Lido Calorini
Dipartimento di Scienze Biomediche Sperimentali e Cliniche “Mario Serio”
Università di Firenze, Viale G.B. Morgagni, 50 I-50134 Firenze, Italy
Tel: 39.0552751286
Fax: 39.0552751281
E-mail: [email protected]

Received date: September 15, 2016; Accepted date: January 20, 2017; Published date: January 25, 2017

Citation: Peppicelli S, Andreucci E, Ruzzolini J, Margheri F, Laurenzana A, et al. (2017) Acidity of Microenvironment as a Further Driver of Tumor Metabolic Reprogramming. J Clin Cell Immunol 8:485. doi: 10.4172/2155-9899.1000485

Copyright: © 2017 Peppicelli S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



In the last decade, experimental research has intensely focused on metabolic reprogramming of tumor cells, which contributes to cancer cell adaptation and survival in different and hostile microenvironments. Metabolic reprogramming consists of the switch of tumor cells from aerobic or anaerobic glycolysis to oxidative phosphorylation. A comprehensive vision of the metabolic scenario involving functionally different tumor cell subpopulations was proposed as a necessary premise to the design of new strategies of diagnosis and therapy. Special focus has been put on the role of acidosis of certain tumor regions, a very important although frequently neglected aspect.

Despite the progresses in cancer therapy, the escaping of tumor cancer cells from host defense and relapse of disease still represent main issues in tumor-bearing patients. Indeed, malignant cells are provided with a tremendous plasticity that they exploit to survive, replicate and invade in stressed microenvironments. Such plasticity allows cancer cells to easily modify their properties, including metabolism, switching back and forth from aerobic or anaerobic glycolysis to oxidative phosphorylation (OxPhos). It is well ascertained that a suitable metabolic profile of cancer cells is necessary to sustain tumor growth, local invasion and distant colonization. Thus, cancer metabolism needs to be considered in view of the design of new strategies to control tumor progression.


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