alexa Activity of Green Algae Extracts against Toxoplasma gondii
ISSN: 2167-0412

Medicinal & Aromatic Plants
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Short Communication

Activity of Green Algae Extracts against Toxoplasma gondii

Jonathan L Powersa1#, Xuejin Zhang1#, Chi Yong Kim1, Daniel A Abugrib2 and William H Witola1*

1Department of Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, IL 61802, USA

2Department of Chemistry, College of Arts and Sciences, Tuskegee University, Tuskegee, Alabama, USA

#Contributed equally

*Corresponding Author:
William H Witola
Department of Pathobiology, College of Veterinary Medicine
University of Illinois, Urbana-Champaign
2001 South Lincoln Avenue, Urbana, IL 61802, USA
Tel: 217-300-3439
Fax: +217-244-7421
E-mail: [email protected]

Received Date: June 07, 2017 Accepted Date: June 20, 2017 Published Date: June 25, 2017

Citation: Powersa JL, Zhang X, Kim CY, Abugrib DA, Witola WH (2017) Activity of Green Algae Extracts against Toxoplasma gondii. Med Aromat Plants (Los Angels) 6: 293. doi:10.4172/2167-0412.1000293

Copyright: © 2017 Powersa JL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Toxoplasma gondii is a zoonotic protozoa of economic significance in livestock. Infected livestock meat and products act as a source of T. gondii infection in humans. Current drugs against T. gondii are limited by hypersensitivity and toxicity, and are not effective against the encysted bradyzoite stage of T. gondii. Thus, there is urgent need for safe and effective therapeutic agents against T. gondii. Marine algae possess potent antifungal and antibacterial properties, but there are no reports on its anti-protozoal activity. Therefore, in this study we obtained nhexane and methanol extracts of green algae (Chlorophyceae) and analyzed their content by high performance liquid chromatography coupled with mass spectrometry, as well as tested their in vitro anti-Toxoplasma activities. Compared to the n-hexane extract of Chlorophyceae, the methanol extract contained higher content of flavonoids/ polyphenols, alkaloids (elaeocarpidine and auramine), and artemisic acid. Importantly, the methanol extract had more potent anti-Toxoplasma activity (IC50=4.43 ± 1.26 μg/mL) than the n-hexane extract (IC50=23.32 ± 3.97 μg/ mL), corroborating the higher content of flavonoids, alkaloids, and artemisic acid in methanol extracts than in nhexane extract. The anti-Toxoplasma IC50 values of the methanol and n-hexane extracts were 34-fold and 7-fold lower than their respective cytotoxic IC50 values in human fibroblast cell line. Consistent with our findings, flavonoids, alkaloids and artemisic acid have previously been shown to have potent anti-Toxoplasma activity. Together, our results show that Chlorophyceae contains significant amounts of bioactive compounds with potent anti-Toxoplasma activity.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords