alexa Activity of Panax ginseng C.A. Meyer on Energy Production in Mammals | OMICS International | Abstract
ISSN: 2167-0501

Biochemistry & Pharmacology: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Activity of Panax ginseng C.A. Meyer on Energy Production in Mammals

Marilou Pannacci1, Valeria Lucini1, Silvana Dugnani1, Rocco Ciracì1, Andrea Zangara2 and Francesco Scaglione1*

1Department of Medical Biotechnology and Translational Medicine, University of Milan, Italy

2Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Australia

*Corresponding Author:
Francesco Scaglione
Professor, Department of Medical Biotechnology and Translational Medicine
University of Milan, Via Vanvitelli 32, 20129- Milan, Italy
Tel: ++39-0250317073
Fax: ++39-0250317050
E-mail: [email protected]

Received date: August 04, 2016; Accepted date: October 14, 2016; Published date: October 19, 2016

Citation: Pannacci M, Lucini V, Dugnani S, Ciracì R, Zangara A, et al. (2016) Activity of Panax ginseng C.A. Meyer on Energy Production in Mammals. Biochem Pharmacol (Los Angel) 5:221. doi:10.4172/2167-0501.1000221

Copyright: © 2016 Pannacci M et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Panax ginseng is traditionally used for enhancement of physical capacities, especially in condition of severe fatigue. To evaluate the ability of ginseng in enhancing performance, we focused on the gene expression of AMPK, PGC-1α and SIRT1 genes, involved in energy balance. Gene expression was evaluated in C2C12 myotubes, using P. ginseng C.A. Meyer standardized extract G115, at various concentrations (10-50-100-200 mg/L) for 24, 48, 72 h of incubation. G115 increased significantly expression of AMPK and PGC-1α in dose and time-dependent manner: at the concentration of 10 mg/L there is an increase after 72 h of incubation while at 50 mg/L after 48 h and maintained for 72 h. G115 increased expression of SIRT1 at 10 mg/L after 24 h, while at 50 mg/L after 24 and 48 h. The treatment enhanced cellular ATP levels and O2 consumption only at 50 mg/L. We investigated AMPK, PGC-1α and SIRT1 expression in gastrocnemius muscle during acute and prolonged exercise in mice treated with G115. G115 showed no effect on acute exercise compared to untreated mice, but after prolonged exercise there were significant increases of AMPK and PGC-1α. Expression of SIRT1 was also significant in treated animals’ undergone prolonged exercise. Our data indicate that treatment with G115 increases AMPK and SIRT1 expression that may be related to the induction of PGC-1α expression which improves the energy balance, as demonstrated by increased production of ATP and oxygen consumption. In addition, G115 is able to counteract the inhibition of gene expression of AMPK and PGC-1α due to the prolonged exercise.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7